Overview and findings from the religious orders study.
Overview and findings from the religious orders study.
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DOI：
10.2174/156720512801322573
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发表时间：
2012-07
影响因子：
2.1
通讯作者：
Wilson RS
中科院分区：
文献类型：
--
作者：
Bennett DA;Schneider JA;Arvanitakis Z;Wilson RS
宗教团体研究是一项针对衰老和阿尔茨海默病 (AD) 的纵向临床病理队列研究。在这篇手稿中，我们总结了研究方法，包括研究设计，并描述了临床评估、风险因素评估、生前生物标本的收集、脑尸检和选定的死后数据的收集。结果：1）回顾了神经病理学指标与临床诊断和临终认知的关系； 2）检查危险因素与临床结果的关系； 3）检查危险因素与神经病理学测量的关系； 4) 总结其他研究结果。然后我们讨论研究结果并将其置于背景中。
The Religious Orders Study is a longitudinal clinical-pathologic cohort study of aging and Alzheimer’s disease (AD). In this manuscript, we summarize the study methods including the study design and describe the clinical evaluation, assessment of risk factors, collection of ante-mortem biological specimens, brain autopsy and collection of selected post-mortem data. The results: 1) review the relation of neuropathologic indices to clinical diagnoses and cognition proximate to death; 2) examine the relation of risk factors to clinical outcomes; 3) examine the relation of risk factors to measures of neuropathology; and 4) summarize additional study findings. We then discuss and contextualize the study findings.