Indifference of marmosets with prenatal valproate exposure to third-party non-reciprocal interactions with otherwise avoided non-reciprocal individuals.
Indifference of marmosets with prenatal valproate exposure to third-party non-reciprocal interactions with otherwise avoided non-reciprocal individuals.
复制标题
产前丙戊酸暴露的狨猴对与其他避免的非互惠个体的第三方非互惠互动表现出冷漠态度。
DOI：
10.1016/j.bbr.2015.06.006
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发表时间：
2015
影响因子：
2.7
通讯作者：
N.
中科院分区：
文献类型：
--
作者：
Yasue;M.;Nakagami;A.;Banno;T.;Nakagaki;K.;Ichinohe;N., Kawai;N.
自闭症的特点是缺乏社会交往和社会认可。虽然自闭症的动物模型已经证明，与对照动物相比，模型动物较少参与社会互动或较少关注同种动物，但还没有动物模型复制自闭症患者在识别复杂社会互动方面的缺陷。在这里，我们表明，绒猴之间的人的演员谁在社会交流中互惠和那些谁没有歧视，然而，绒猴胎儿暴露于丙戊酸（VPA绒猴）没有。在互惠条件下，两个行动者平等地交换食物，而在非互惠条件下，一个行动者（非互惠者）最终得到所有食物，另一个行动者没有食物。在观察到这些交换后，对照组绒猴避免在非互惠条件下接受来自非互惠者的食物。然而，VPA绒猴在这两种情况下都没有表现出不同的偏好，这表明VPA绒猴没有区分互惠和非互惠的相互作用。这些结果表明，正常的绒猴可以评估第三方之间的社会互动，而VPA绒猴无法识别个体是否是互惠的。这个测试组合可以作为一个有用的工具，以资格灵长类动物模型的自闭症。
Autism is characterized by deficits in social interaction and social recognition. Although animal models of autism have demonstrated that model animals engage less in social interaction or attend less to conspecifics than control animals, no animal model has yet replicated the deficit in recognition of complex social interaction as is seen in humans with autism. Here, we show that marmosets discriminated between human actors who reciprocated in social exchanges and those who did not; however, marmosets with foetal exposure to valproic acid (VPA marmosets) did not. In the reciprocal condition, two actors exchanged food equally, while in the non-reciprocal condition, one actor (non-reciprocator) ended up with all food and the other actor with none. After observing these exchanges, the control marmosets avoided receiving food from the non-reciprocator in the non-reciprocal condition. However, the VPA marmosets did not show differential preferences in either condition, suggesting that the VPA marmosets did not discriminate between reciprocal and non-reciprocal interactions. These results indicate that normal marmosets can evaluate social interaction between third-parties, while the VPA marmosets are unable to recognize whether an individual is being reciprocal or not. This test battery can serve as a useful tool to qualify primate models of autism.