Specific labelling of brain receptors with [3H]N-acetyl-aspartyl-glutamate.
Specific labelling of brain receptors with [3H]N-acetyl-aspartyl-glutamate.
复制标题
用 [3H]N-乙酰基-天冬氨酰-谷氨酸对脑受体进行特异性标记。
DOI：
10.1016/0014-2999(84)90392-3
复制
发表时间：
1984
影响因子：
5
通讯作者：
Coyle,JT
中科院分区：
文献类型：
--
作者：
Koller,KJ;Coyle,JT
[en]N-乙酰-N-乙酰基谷氨酸（NAAG）是脑内源性肽，对（3 H）L-谷氨酸标记的脑受体位点亚群表现出高亲和力。NAAG的兴奋作用与L-谷氨酸本身不同，可被2-氨基-5-膦酰基丁酸（APB）拮抗。作者的结果表明[3 H] NAAG是一个有用的配体，用于表征这一亚群的谷氨酸受体。（Auth.）
[en] N-Acetyl-aspartyl glutamate (NAAG) is a peptide endogenous to brain that exhibits high affinity for a subpopulation of brain receptor sites labeled with (3 H) L-glutamate. The excitatory effects of NAAG are, unlike those of l-glutamate itself, antagonized by 2-amino-5-phosphono-butyric acid (APB). The authors' results indicate that [3 H] NAAG is a useful ligand for characterizing this subpopulation of glutamate receptors.(Auth.)