A compilation of fatal and control concentrations of drugs in postmortem femoral blood.
A compilation of fatal and control concentrations of drugs in postmortem femoral blood.
复制标题
死后股血中药物致命浓度和对照浓度的汇编。
DOI：
10.1520/jfs14071j
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发表时间：
1997
影响因子：
1.6
通讯作者：
Per Holmgren
中科院分区：
文献类型：
--
作者：
Henrik Druid;Per Holmgren
汇编死后股血药物浓度。这些样本是从死亡原因为以下情况的病例中收集的：A）经证明仅由一种物质引起的中毒，B）经证明由一种以上物质和/或酒精引起的中毒，以及C）经证明的非药物所致失能的其他死因。将这些浓度与在疑似吸毒司机（D）中检测到的血液浓度以及先前公布的致命和治疗浓度进行比较。本汇编的特点是：1）仅引用股血浓度，2）所有分析均基于根据标准化质量控制程序处理的样本，3）包括两个对照组，4）仅一种物质中毒与其他中毒分开。这些材料是根据1992年至1995年期间从瑞典六个法医病理学单位送往瑞典林雪平法医化学部的15，800个样本中挑选出来的，清单包括83种药物。该汇编包括以前公布的数据很少的药物。此外，从中毒以外的其他死因病例（C组）中收集的数据构成了一种新的参考信息，可能比任何活体治疗浓度汇编更好地估计了死后血液中明显非致命的浓度。讨论了影响死后药物浓度的可能因素。
A compilation of postmortem femoral blood concentrations of drugs is presented. The samples are collected from cases in which the cause of death was: A) certified intoxication by one substance alone, B) certified intoxication by more than one substance and/or alcohol, and C) certified other cause of death without incapacitation due to drugs. The concentrations were compared with blood concentrations detected in suspected drugged drivers (D), and with previously published fatal and therapeutic concentrations. The special features of this compilation are: 1) exclusively femoral blood concentrations are quoted, 2) all analyses are based on samples handled according to a standardized, quality-controlled procedure, 3) two control groups are included, and 4) one-substance-only intoxications are separated from other intoxications. The material is based on a selection of 15,800 samples sent to the Department of Forensic Chemistry in Linköping, Sweden, during 1992 to 1995 from the six forensic pathology units in Sweden, and the list includes 83 drugs. The compilation includes drugs, where previously published data are scarce. Furthermore, the data gathered from cases with other cause of death than intoxication (group C) constitute a new kind of reference information, which probably offers a better estimate of obviously non fatal levels in postmortem blood than any compilation of therapeutic concentrations in living subjects. The possible factors influencing postmortem drug concentrations are discussed.