Myelination and organization of the frontal white matter in children: a diffusion tensor MRI study
Myelination and organization of the frontal white matter in children: a diffusion tensor MRI study
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DOI：
10.1097/00001756-199909090-00022
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发表时间：
1999-09-09
期刊：
影响因子：
1.7
通讯作者：
Hedehus, M
中科院分区：
文献类型：
--
作者：
Klingberg, T;Vaidya, CJ;Hedehus, M
髓鞘形成对大脑的功能发育至关重要，但儿童期髓鞘形成的时间进程尚不清楚。磁共振扩散张量成像（DTI）提供了一种新的方法来估计体内髓鞘形成。髓磷脂限制水横向于轴突的扩散，导致扩散各向异性。通过量化各向异性，可以研究轴突的进行性髓鞘形成。额叶的中央白色物质在7名儿童（平均年龄10岁）和5名成人（平均年龄27岁）进行了研究。儿童额叶白色物质的各向异性显著低于成人，表明儿童的髓鞘形成较少。白色物质的相干性测量显示，无论是儿童还是成人，右侧额叶都比左侧额叶有一个更规则的轴突组织。结果表明，额叶白色物质的成熟持续到生命的第二个十年。前额叶成熟的时间过程使得髓鞘形成可能是前额叶功能逐渐发展的基础，例如增加工作记忆容量。(C)1999年利平科特威廉姆斯&威尔金斯。
MYELINATION is critical for the functional development of the brain, but the time course of myelination during childhood is not well known. Diffusion tensor MR imaging (DTI) provides a new method for estimating myelination in vivo. Myelin restricts diffusion of water transverse to the axons, causing diffusion to be anisotropic. By quantifying the anisotropy, the progressive myelination of axons can be studied. Central white matter of the frontal lobe was studied in seven children (mean age 10 years) and five adults (mean age 27 years). Anisotropy in the frontal white matter was significantly lower in children than in adults, suggesting less myelination in children. Measurement of the coherence of white matter revealed that the right frontal lobe had a than the left more regular organization of axons frontal lobe, in both children and adults. The results demonstrate that maturation of the frontal white matter continues into the second decade of life. The time course of prefrontal maturation makes it possible that myelination is a basis for the gradual development of prefrontal functions, such as increased working memory capacity. (C) 1999 Lippincott Williams & Wilkins.