A new anorexigenic protein, nesfatin-1
A new anorexigenic protein, nesfatin-1
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DOI：
10.1016/j.peptides.2009.01.002
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发表时间：
2009-05-01
期刊：
影响因子：
3
通讯作者：
Mori, Masatomo
中科院分区：
文献类型：
--
作者：
Shimizu, Hiroyuki;Ohsaki, Aya;Mori, Masatomo
在大鼠下丘脑中发现了一种抑制食欲的肽nesfatin-1，其在下丘脑室旁核中的表达因饥饿而减少。脑室内给药剂量依赖性地抑制雄性 Wistar 和瘦素抵抗的 Zucker 脂肪大鼠的食物摄入 6 小时。大脑中nesfatin-1通路和黑皮质素通路之间可能存在串扰。 Nesfatin-1 神经元与下丘脑中的催产素、加压素和黑色素浓缩激素共同表达。腹腔注射nesfatin-1及其中段剂量依赖性地抑制食物摄入3小时。 nesfatin-1 的中段可减少瘦素抵抗性肥胖动物模型的食物摄入量。腹腔内给予中段nesfatin-1可增加孤束核中阿黑皮素原、可卡因和安非他明相关肽的mRNA表达，但在下丘脑弓状核中则不增加。本文综述了nesfatin-1引起厌食症可能机制的研究进展。 (C) 2009 年，爱思唯尔公司出版。
An anorexigenic peptide, nesfatin-1 was found in rat hypothalamus, and its expression in the paraventricular nucleus of the hypothalamus was reduced by starvation. Intracerebroventricular administration dose-dependently inhibited food intake for 6 h in male Wistar and leptin resistant, Zucker fatty rats. There may be a crosstalk between nesfatin-1 pathway and melanocortin pathway in the brain. Nesfatin-1 neurons co-express with oxytocin, vasopressin and melanin concentrating hormone in the hypothalamus. Intraperitoneal administration of nesfatin-1 and its mid-segment dose-dependently inhibited food intake for 3 h. Mid-segment of nesfatin-1 decreased food intake under leptin-resistant animal models of obesity. Intraperitoneal administration of the mid-segment of nesfatin-1 increased proopiomelanocortin and cocain- and amphetamine-related peptide mRNA expression in the nucleus of the solitary tract, but not in arcuate nucleus of the hypothalamus. In this review, we summarized recent progress in the research about the possible mechanism of nesfatin-1-induced anorexia. (C) 2009 Published by Elsevier Inc.