Camrelizumab and apatinib plus induction chemotherapy and concurrent chemoradiotherapy in stage N3 nasopharyngeal carcinoma: a phase 2 clinical trial.
Camrelizumab and apatinib plus induction chemotherapy and concurrent chemoradiotherapy in stage N3 nasopharyngeal carcinoma: a phase 2 clinical trial.
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DOI：
10.1038/s41467-024-45126-0
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发表时间：
2024-02-03
影响因子：
16.6
通讯作者：
Xiang, Yan-Qun
中科院分区：
文献类型：
--
作者：
Liang, Hu;Jiang, Yao-Fei;Liu, Guo-Ying;Wang, Lin;Wang, Jian-Wei;Lu, Nian;Xia, Wei-Xiong;Ke, Liang-Ru;Ye, Yan-Fang;Duan, Jin-Lin;Bei, Wei-Xin;Dong, Shu-Hui;Li, Wang-Zhong;Liu, Li-Ting;Zhao, Chong;Xie, Changqing;Xiang, Yan-Qun
The antiangiogenic agent apatinib has been shown to clinically improve responses to immune checkpoint inhibitors in several cancer types. Patients with N3 nasopharyngeal carcinoma have a high risk of distant metastasis, however, if the addition of immunotherapy to standard treatment could improve efficacy is unclear. In this phase II clinical trial (ChiCTR2000032317), 49 patients with stage TanyN3M0 nasopharyngeal carcinoma were enrolled and received the combination of three cycles of induction chemotherapy, camrelizumab and apatinib followed by chemoradiotherapy. Here we report on the primary outcome of distant metastasis-free survival and secondary end points of objective response rate, failure-free survival, locoregional recurrence-free survival, overall survival and toxicity profile. After induction therapy, all patients had objective response, including 13 patients (26.5%) with complete response. After a median follow-up of 28.7 months, the primary endpoint of 1-year distant metastasis-free survival was met for the cohort (1-year DMFS rate: 98%). Grade≥3 toxicity appeared in 32 (65.3%) patients, with the most common being mucositis (14[28.6%]) and nausea/vomiting (9[18.4%]). In this work, camrelizumab and apatinib in combination with induction chemotherapy show promising distant metastasis control with acceptable safety profile in patients with stage TanyN3M0 nasopharyngeal carcinoma. The antiangiogenic agent apatinib has been shown to clinically improve responses to immune checkpoint inhibitors in several cancer types. Here the authors report the results of a phase II clinical trial of camrelizumab (anti-PD1) and apatinib plus induction chemotherapy and concurrent chemoradiotherapy in stage N3 nasopharyngeal carcinoma.
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影响因子：
50.3
作者：
Jain RK
通讯作者：
Jain RK
调强放射治疗时代流行地区鼻咽癌第 8 版 UICC/AJCC 分期系统的验证。
DOI：
10.6004/jnccn.2017.0121
发表时间：
2017-07-01
影响因子：
13.4
作者：
Tang, Ling-Long;Chen, Yu-Pei;Ma, Jun
通讯作者：
Ma, Jun
DOI：
10.1186/1748-717x-8-265
发表时间：
2013-11-13
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Sun X;Zeng L;Chen C;Huang Y;Han F;Xiao W;Liu S;Lu T
通讯作者：
Lu T
影响因子：
11.5
作者：
Li, Qian;Wang, Yifan;Liu, Jieqiong
通讯作者：
Liu, Jieqiong
影响因子：
168.9
作者：
Chen, Yu-Pei;Liu, Xu;Ma, Jun
通讯作者：
Ma, Jun