Cross-modal integration of intranasal stimuli: A functional magnetic resonance imaging study
Cross-modal integration of intranasal stimuli: A functional magnetic resonance imaging study
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DOI：
10.1016/j.neuroscience.2007.06.045
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发表时间：
2007-10-12
期刊：
影响因子：
3.3
通讯作者：
Hummel, T.
中科院分区：
文献类型：
--
作者：
Boyle, J. A.;Frasnelli, J.;Hummel, T.
除了嗅觉系统之外，大多数气味剂还激活鼻内三叉神经系统。最近的研究表明，单纯的三叉神经刺激激活体感区域以及传统上被认为是主要嗅觉区域的区域。作为本研究的主要目的，我们希望a）确定哪些脑区对由三叉神经（CO2）和嗅觉刺激剂（苯乙醇，PEA）组成的“人工”双峰气味有反应，以及B）确定同时呈现CO2和PEA是否激活了与单独呈现时不同的脑区。15名男性使用功能性磁共振成像进行扫描，同时闻到PEA，CO2以及同时呈现的两种刺激的混合物（CO（2）PEA）。在区组设计中，气味被单鼻地呈现在右侧鼻孔。CO（2）PEA和基线之间的对比揭示了涉及嗅觉和三叉神经刺激处理的区域。当混合物与其单一成分的总和（CO（2）PEA-{CO2+PEA}）进行对比时，检测到整合中心（左上级颞和右顶内沟）和眶额区（左内侧和外侧眶额皮质）的激活。相反的对比（{CO2+PEA}-CO（2）PEA）没有显示任何显著的激活。与使用天然混合嗅觉/三叉神经刺激的研究相反，我们已经表明，人工混合嗅觉/三叉神经刺激的感知激活，而不是抑制嗅觉皮层。此外，我们还得出结论，混合嗅觉/三叉神经刺激似乎导致更高的皮层激活比其部分的总和。(c)2007年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Most odorants, in addition to the olfactory system, also activate the intranasal trigeminal system. Recent studies have shown that pure trigeminal stimulation activates somatosensory regions as well as regions traditionally thought of as primary olfactory areas. As a main aim of this study we wished to a) ascertain which brain regions are responsive to an "artificially" bimodal odor composed of a trigeminal (CO2) and an olfactory stimulant (phenyl ethyl alcohol, PEA) and b) determine if presenting CO2 and PEA simultaneously activates different brain regions than when presenting them individually. Fifteen men were scanned using functional magnetic resonance imaging while smelling PEA, CO2, and a mixture of both Stimuli (CO(2)PEA) presented simultaneously. Odors were presented monorhinally to the right nostril in a block design. The contrast between CO(2)PEA and baseline revealed areas implicated in the processing of both olfactory and trigeminal stimuli. When the mixture was contrasted with the sum of its single components (CO(2)PEA-{CO2+PEA}), activations in integration centers (left superior temporal and right intraparietal sulcus) and in orbitofrontal areas (left medial and lateral orbitofrontal cortex) were detected. The opposite contrast ({CO2+PEA}-CO(2)PEA) did not reveal any significant activation. In contrast to studies which have used natural mixed olfactory/trigerninal stimuli, we have shown that the perception of an artificial mixed olfactory/trigerninal stimulus activates, as opposed to inhibiting the olfactory cortex. Further, we also conclude that a mixed olfactory/ trigeminal stimulus appears to lead to higher cortical activations than the sum of its parts. (c) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.