Multicenter collaboration study on the β-lactam resistant Enterobacteriaceae in Japan - The 65th anniversary public interest purpose project of the Japanese Society of Chemotherapy
Multicenter collaboration study on the β-lactam resistant Enterobacteriaceae in Japan - The 65th anniversary public interest purpose project of the Japanese Society of Chemotherapy
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DOI：
10.1016/j.jiac.2017.06.009
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发表时间：
2017-09-01
影响因子：
2.2
通讯作者：
Kiyota, Hiroshi
中科院分区：
文献类型：
--
作者：
Ishii, Yoshikazu;Aoki, Kotaro;Kiyota, Hiroshi
本研究采用与“艰难梭菌感染性1天多中心协作研究”相同的方法进行。这项监测研究由日本各地的38家参与医疗机构进行。在本研究中采集的268份粪便标本中，根据日本传染病法案的标准（亚胺培南和头孢美唑的MIC分别为2 mg/L或更高和64 mg/L或更高），5份（1.9%）碳青霉烯类耐药肠杆菌科（CRE）被判定为碳青霉烯类耐药。然而，没有分离物显示具有2 mg/L或更高的美罗培南MIC。CRE中未检出碳青霉烯酶编码基因。产超广谱β-内酰胺酶（ESBL）肠杆菌科细菌29株（11%），其优势基因群为bla（CTX-M-9）。ESBL编码基因阳性大肠埃希菌多位点序列分型以ST 131为主。(C)2017年日本化疗学会和日本传染病协会。由爱思唯尔有限公司出版。保留所有权利。
This study was conducted using the same method of the "1-day multicenter collaborative research for Clostridium difficile infectious". This surveillance study was performed by 38 participating medical facilities across Japan. Of the 268 fecal specimens collected in this study, 5 (1.9%) carbapenem-resistant Enterobacteriaceae (CRE) were judged carbapenem resistant by the criteria of the Infectious Disease Act, Japan (2 mg/L or more and 64 mg/L or more MICs for imipenem and cefmetazole, respectively). However, no isolate was shown to have a meropenem MIC of 2 mg/L or more. No carbapenemase encoding genes were detected from the CRE. Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae were detected from 29 specimens (11%), and the predominant ESBL-encoding gene group was bla(CTX-M-9). The predominant ST-type by multilocus sequence typing of ESBL encoding gene-positive Escherichia coli was ST131. (C) 2017 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.