Agent-based modeling of multicell morphogenic processes during development
Agent-based modeling of multicell morphogenic processes during development
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DOI：
10.1002/bdrc.20106
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发表时间：
2007-12-01
影响因子：
2.1
通讯作者：
Peirce, Shayn M.
中科院分区：
文献类型：
--
作者：
Thorne, Bryan C.;Bailey, Alexander M.;Peirce, Shayn M.
发育生物学领域的一个中心挑战是理解生物尺度的一个水平上的机制（即，细胞水平）相互作用以产生更高水平（即，组织水平）现象。这一挑战与组织形态发生的研究特别相关，组织形态发生是产生新形成、重塑或再生组织结构的过程。形态发生源于个体细胞彼此之间及其与局部环境的空间和时间动态相互作用。计算模型与实验努力相结合，以加速发现过程。基于代理的建模（ABM）是一种计算技术，可用于对单个生物细胞的集合进行建模并计算它们的相互作用，从而产生紧急的组织水平结果。最近，ABM已被应用到各种发育形态发生过程的研究，本文的目的是总结这些研究，以证明可以预期的类型的进展，从追求多细胞ABM的方法。我们还强调了与反弹道导弹有关的一些挑战，并提出了克服这些挑战的战略。虽然ABM的应用研究生态学，流行病学和社会科学有一个更长的历史，我们认为，应用ABM的形态发生的研究有很大的效用，当与台式实验配对，ABM可以提供新的见解和指导未来的实验。
A central challenge in the field of developmental biology is to understand how mechanisms at one level of biological scale (i.e., cell-level) interact to produce higher-level (i.e., tissue-level) phenomena. This challenge is particularly relevant to the study of tissue morphogenesis, the process that generates newly formed, remodeled, or regenerated tissue structures. Morphogenesis arises from the spatially- and temporally-dynamic interactions of individual cells with each other and their local environment. Computational models have been combined with experimental efforts to accelerate the discovery processes. Agent-based modeling (ABM) is a computational technique that can be Used to model collections of individual biological cells and compute their interactions, which generate emergent tissue-level results. Recently, ABM has been applied to the study of various developmental morphogenic processes, and the purpose of this review is to summarize these studies in order to demonstrate the types of advances that can be expected from pursuing a multicell ABM approach. We also highlight some challenges associated with ABM and suggest strategies for overcoming them. While ABM's application to the study of ecology, epidemiology, and social sciences has a much longer history, we suggest that the application of ABM to the study of morphogenesis has great utility, and when paired with benchtop experimentation, ABM can provide new insights and direct future experimentation.