Effects of the NMDA receptor antagonist MK-801 on short-interval timing in rats.
Effects of the NMDA receptor antagonist MK-801 on short-interval timing in rats.
复制标题
NMDA 受体拮抗剂 MK-801 对大鼠短间隔时间的影响。
DOI：
10.1037/0735-7044.120.1.162
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发表时间：
2006
影响因子：
1.9
通讯作者：
Pang,KevinCH
中科院分区：
文献类型：
--
作者：
Miller,JonathanP;McAuley,JDevin;Pang,KevinCH
用峰间期(PI)法和PI-GAP法观察N-甲基-D-天冬氨酸拮抗剂MK-801对短时间间隔计时的影响。Fisher 344大鼠每天注射0.025 mg/kg、0.05 mg/kg和0.2 mg/kg的MK-801。主要结果是：(A)0.2 mg/kg MK-801立即高估了标准时间；(B)MK-801增加了反应的峰值速度；(C)0.2 mg/kg MK-801增加了变异性；(D)在PI-GAP过程中，所有大鼠(MK-801和生理盐水)都观察到了重置模式。结果表明，MK-801至少有两种作用。首先，MK-801通过高估时间和变异性的非标量增加来干扰短间隔计时。其次，MK-801提高了响应速度，表明响应抑制减少。(心理信息数据库记录(C)2016 APA，版权所有)
Effects of MK-801, an N-methyl-D-aspartate antagonist, on short-interval timing were examined using the peak-interval (PI) and PI-gap procedures. Fisher 344 rats were given daily injections of 0.025 mg/kg, 0.05 mg/kg, and 0.2 mg/kg MK-801. The main results were (a) 0.2 mg/kg MK-801 produced an immediate overestimation of the criterion time;(b) MK-801 increased peak rate of responding;(c) 0.2 mg/kg MK-801 produced an increase in variability;(d) during the PI-gap procedure, a reset pattern was observed for all rats (MK-801 and saline). Results suggest that MK-801 has at least 2 effects. First, MK-801 interferes with short-interval timing by producing an overestimation of time and a nonscalar increase in variability. Second, MK-801 increases response rate, suggesting a decrease in response inhibition.(PsycINFO Database Record (c) 2016 APA, all rights reserved)