Effectiveness and safety of influenza vaccination in children: European perspective
Effectiveness and safety of influenza vaccination in children: European perspective
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DOI：
10.1016/j.vaccine.2011.08.011
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发表时间：
2011-10-06
期刊：
影响因子：
5.5
通讯作者：
Heinonen, Santtu
中科院分区：
文献类型：
--
作者：
Heikkinen, Terho;Heinonen, Santtu
越来越多的证据表明，流感对儿童造成了巨大的负担，这增加了对幼儿接种流感疫苗的兴趣。然而，到目前为止，很少有欧洲国家发布官方建议为健康儿童接种疫苗，这主要是因为人们普遍认为灭活流感疫苗对幼儿无效。在不同季节进行的经病毒学证实的研究对疫苗有效性的估计差异很大，并表明疫苗与流行的流感病毒株之间的匹配是疫苗有效性的关键驱动因素之一。在抗原匹配良好的季节，灭活流感疫苗对2岁以下儿童也明显有效。减毒活流感疫苗在儿童中提供更大的有效性，但这种疫苗的总体潜力受到其仅用于2岁以上儿童的许可的限制。季节性灭活流感疫苗的安全记录非常好，即使在最年幼的儿童中也是如此。(C)2011爱思唯尔有限公司保留所有权利。
Accumulating evidence for the substantial burden of influenza in children has increased interest in the vaccination of young children against influenza. So far, however, few European countries have issued official recommendations to vaccinate healthy children, which is largely due to the popular belief that inactivated influenza vaccines are ineffective in young children. Virologically confirmed studies performed during different seasons have yielded widely varying estimates for vaccine effectiveness and suggested that the match between the vaccine and the circulating strains of influenza viruses is one of the key drivers of the effectiveness of the vaccine. In seasons with good antigenic match, inactivated influenza vaccines are clearly effective also in children younger than 2 years of age. The live attenuated influenza vaccine provides even greater effectiveness in children, but the overall potential of this vaccine is limited by its licensure for only children older than 2 years of age. The safety record of seasonal inactivated influenza vaccines is excellent even in the youngest children. (C) 2011 Elsevier Ltd. All rights reserved.