Antidiabetic and antihyperlipidaemic activity of ethanol extract of Melastoma malabathricum Linn. leaf in alloxan induced diabetic rats
Antidiabetic and antihyperlipidaemic activity of ethanol extract of Melastoma malabathricum Linn. leaf in alloxan induced diabetic rats
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DOI：
10.12980/apjtb.4.2014c122
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发表时间：
2014-05-01
影响因子：
1.7
通讯作者：
Mohan, Veerabahu Ramasamy
中科院分区：
文献类型：
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作者：
Balamurugan, Karuppasamy;Nishanthini, Antony;Mohan, Veerabahu Ramasamy
目的：评价马拉黑草醇提物的降糖、降血脂作用。四氧嘧啶诱导的糖尿病大鼠叶片。方法：采用一水四氧嘧啶（150mg /kg i.p）诱导白化大鼠糖尿病。以150和300 mg/kg体重剂量的马拉巴草叶提取物，每天单次给药，连续给药14 d。观察马拉巴草叶提取物对糖尿病大鼠血糖、血浆胰岛素、肌酐、糖化血红蛋白、尿素血脂[总胆固醇、甘油三酯、低密度脂蛋白-胆固醇、极低密度脂蛋白-胆固醇]的影响。测定糖尿病大鼠高密度脂蛋白-胆固醇和磷脂、血清蛋白、白蛋白、球蛋白、血清酶（谷氨酸丙酮酸转氨酶）、谷氨酸草酰乙酸转氨酶和碱性磷酸酶。结果：在急性毒性试验中，2 000 mg/kg的乙醇提取物对大鼠无毒。与糖尿病对照大鼠相比，两种剂量的麦冬叶乙醇提取物均使糖尿病大鼠体重增加，血糖、糖化血红蛋白等生化指标降低。在糖尿病大鼠中，与糖尿病对照大鼠相比，麦冬叶乙醇提取物改变后的血脂谱恢复到接近正常水平。结论：麦冬叶乙醇提取物对糖尿病大鼠具有明显的降糖、降血脂作用。
Objective: To evaluate the antidiabetic and antihyperlipidaemic effect of ethanol extract of Melastoma malabathricum (M. malabathricum) Linn. leaf in alloxan induced diabetic rats.Methods: Diabetes was induced in albino rats by administration of alloxan monohydrate (150 mg/kg i.p). the ethanol extracts of M. malabathricum at a dose of 150 and 300 mg/kg of body weight were administrated at a single dose per day to diabetes induced rats for a period of 14 d. The effect of ethanol extract of M. malabathricum leaf extract on blood glucose, plasma insulin, creatinine, glycosylated haemoglobin, urea serum lipid profile [total cholesterol, triglycerides, low density lipoprotein-cholesterol, very low density lipoprotein-cholesterol, high density lipoprotein-cholesterol and phospholipid, serum protein, albumin, globulin, serum enzymes (serum glutamate pyruvate transaminases), serum glutamate oxaloacetate transaminases, and alkaline phosphatase] were measured in the diabetic rats.Results: In the acute toxicity study, ethanol extract of M. malabathricum leaf was non-toxic at 2 000 mg/kg in rats. The increased body weight, decreased blood glucose, glycosylated haemoglobin and other biochemical parameters level were observed in diabetic rats treated with both doses of ethanol extract of M. malabathricum leaf compared to diabetic control rats. In diabetic rats, ethanol extract of M. malabathricum leaf administration, altered lipid profiles were reversed to near normal than diabetic control rats.Conclusions: Ethanol extract of M. malabathricum leaf possesses significant antidiabetic and antihyperlipidaemic activity in diabetic rats.