Prospective evaluation of body weight and body fat distribution in early postmenopausal women with and without hormonal replacement therapy
Prospective evaluation of body weight and body fat distribution in early postmenopausal women with and without hormonal replacement therapy
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DOI：
10.1016/s0378-5122(01)00194-3
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发表时间：
2001-08-25
期刊：
影响因子：
4.9
通讯作者：
Genazzani, AR
中科院分区：
文献类型：
--
作者：
Gambacciani, M;Ciaponi, M;Genazzani, AR
目的：为了评估绝经和激素替代疗法（HRT）对体重和体脂分布（通过双能X射线测定）的影响，早期绝经后妇女口服钙（500 mg/天，对照组，n = 13）或HRT，戊酸雌二醇（EV，2 mg/天，持续21天）与醋酸环丙孕酮（CPA）的组合。在治疗周期的最后10天，1 mg/天，n = 18; Climen（（R）），Schering）。结果：实验前两组基础体重和体脂分布无差异。在对照组中，（P < 0.05）体重增加（36个月后从63.5 +/- 2.0 kg降至68.7 +/- 2.0 kg）-转变为普遍的中心，android脂肪分布有轻微但显著的（P < 0.05）增加总体脂肪量（从23.4 +/- 2.1至29.1 +/- 2.1 kg），躯干增加（从10.1 +/- 0.4到12.7 +/- 0.4 kg，P < 0.05），手臂（从2.4 +/- 0.2到2.9 +/- 0.2 kg，P < 0.05）和腿部（从6.5 +/- 0.4到7.8 +/- 0.4 kg，P < 0.05）脂肪。HRT组全身骨矿物质含量显著增加（从1086 +/- 21至1128 +/- 19 mg/cm（2），P < 0.05），36个月后增加，体重无显著增加（从62.6 +/- 1.8至65.0 +/- 1.9 kg），躯干无变化（从10.0 +/- 0.2至10.1 +/- 0.2 kg）和组（从2.4 +/- 0.1到2.6 +/- 0.1 kg）脂肪，但腿部脂肪显著增加（从6.9 +/- 0.3到9.9 +/- 0.4 kg，P < 0.05）。结论：目前的研究结果表明，更年期与体重和体脂的加速增加有关，具有普遍的中央，android脂肪分布，可以至少部分地通过口服HRT抵消。(C)2001爱思唯尔科学爱尔兰有限公司。保留所有权利。
Aims: In order to assess the effects of menopause and hormonal replacement therapy (HRT) on body weight and body fat distribution (determined by dual energy X-ray), early postmenopausal women were given either oral calcium (500 mg/day, control group, n = 13) or HRT, a combination of estradiol valerate (EV, 2 mg/day for 21 days) with cyproterone acetate (CPA. I mg/day in the last 10 days of the treatment cycle, n = 18; Climen((R)), Schering). Results: There were no differences in basal body weight and body fat distribution in the two groups before the study. In control group, a significant (P < 0.05) increase in body weight (from 63.5 +/- 2.0 to 68.7 +/- 2.0 kg after 36 months) paralleled a shift to a prevalent central, android fat distribution with a slight but significant (P < 0.05) increase in total body fat mass (from 23.4 +/- 2.1 to 29.1 +/- 2.1 kg), an increase in trunk (from 10.1 +/- 0.4 to 12.7 +/- 0.4 kg, P < 0.05), arms (from 2.4 +/- 0.2 to 2.9 +/- 0.2 kg, P < 0.05) and legs (from 6.5 +/- 0.4 to 7.8 +/- 0.4 kg P < 0.05) fat. In the HRT group total body bone mineral showed a significant increase (from 1086 +/- 21 to 1128 +/- 19 mg/cm(2), P < 0.05) increase after 36 months, with no significant increase in body weight (from 62.6 +/- 1.8 to 65.0 +/- 1.9 kg), and no modifications in trunk (from 10.0 +/- 0.2 to 10.1 +/- 0.2 kg) and arms (from 2.4 +/- 0.1 to 2.6 +/- 0.1 kg) fat, but a significant increase in legs fat (from 6.9 +/- 0.3 to 9.9 +/- 0.4 kg, P < 0.05). Conclusion: Present results demonstrate that menopause is associated with an accelerated increase in body weight and body fat, with a prevalent central, android fat distribution, that can be counteracted at least in part by oral HRT. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.