Zinc(II)-curcumin accelerates the healing of acetic acid-induced chronic gastric ulcers in rats by decreasing oxidative stress and downregulation of matrix metalloproteinase-9
Zinc(II)-curcumin accelerates the healing of acetic acid-induced chronic gastric ulcers in rats by decreasing oxidative stress and downregulation of matrix metalloproteinase-9
复制标题
DOI：
10.1016/j.fct.2013.07.075
复制
发表时间：
2013-10-01
影响因子：
4.3
通讯作者：
Xu, Shi-Bo
中科院分区：
文献类型：
--
作者：
Mei, Xue-Ting;Xu, Dong-Hui;Xu, Shi-Bo
胃溃疡的形成是多方面过程的结果，包括酸分泌、活性氧产生和细胞外基质（ECM）降解。本研究的目的是调查潜在的抗溃疡作用的Zn（II）-姜黄素络合物，姜黄素衍生物，对乙酸诱导的大鼠胃溃疡愈合的可能机制。与假手术组相比，对照组大鼠重度溃疡胃粘膜谷胱甘肽（GSH）含量和超氧化物歧化酶（SOD）活性降低，丙二醛（MDA）含量升高（P < 0.001）。Zn（II）-姜黄素固体分散体（相当于12、24和48 mg/kg）剂量依赖性地降低胃溃疡指数，显著提高胃粘膜SOD活性和GSH水平，降低MDA含量和基质金属蛋白酶-9（MMP-9）mRNA表达（与对照组相比，P < 0.05）。Zn（II）-姜黄素的抗溃疡作用明显强于相同剂量（24 mg/kg）的姜黄素（P < 0.05），可减轻胃溃疡的严重程度，降低MDA含量，提高SOD活性和GSH水平（P < 0.05）。总之，这些结果证实，与单独的姜黄素相比，Zn（II）-姜黄素复合物具有增强的粘膜屏障防御活性，这是由于其降低氧化应激和减弱MMP-9介导的炎症的协同能力。皇冠版权所有（C）2013由爱思唯尔有限公司出版。保留所有权利。
Gastric ulcers form as a result of a multifaceted process which includes acid secretion, reactive oxygen species generation and extracellular matrix (ECM) degradation. The aim of this study was to investigate the possible mechanisms underlying the anti-ulcerogenic effects of the Zn(II)-curcumin complex, a curcumin derivative, on the healing of acetic acid-induced gastric ulcers in rats. The severely ulcerated gastric mucosa of control animals had a lower glutathione level (GSH) and superoxide dismutase activity (SOD), and increased malondialdehyde (MDA) content compared to sham operated rats (P < 0.001). Zn(II)-curcumin solid dispersions (equivalent to 12, 24 and 48 mg/kg) dose-dependently reduced the gastric ulcer index, significantly increased SOD activity and GSH levels, and reduced the MDA content and matrix metalloproteinase-9 (MMP-9) mRNA expression in the gastric mucosa (P < 0.05, compared to control animals). Zn(II)-curcumin exerted a greater anti-ulcerogenic effect than curcumin at the same dose (24 mg/kg), leading to a reduced severity of gastric ulcers, lower MDA content, and increased SOD activity and GSH levels (P < 0.05). In conclusion, these results confirm that the Zn(II)-curcumin complex possesses an enhanced mucosal barrier defense activity compared to curcumin alone, due to its synergistic ability to decrease oxidative stress and attenuate MMP-9-mediated inflammation. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.