The evolving crosstalk between co-stimulatory and co-inhibitory receptors: HVEM-BTLA
The evolving crosstalk between co-stimulatory and co-inhibitory receptors: HVEM-BTLA
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DOI：
10.1016/j.it.2005.03.010
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发表时间：
2005-06-01
影响因子：
16.8
通讯作者：
Croft, M
中科院分区：
文献类型：
--
作者：
Croft, M
T细胞和抗原呈递细胞上的受体及其配体对于传递抑制或刺激信号至关重要，这些信号使免疫细胞保持休眠或有效地对各种刺激做出反应。CD 28-B7和肿瘤坏死因子受体（TNFR）-TNF超家族包含许多这些分子，并被认为是不同的功能模块。然而，两项研究现在在这个已经复杂的领域提供了一个新的视角，不仅显示了这些超家族之间的串扰，而且还显示了共刺激和共抑制受体之间的潜在串扰。
Receptors and their ligands on T cells and antigen-presenting cells are crucial for delivering inhibitory or stimulatory signals that enable immune cells to remain dormant or to respond effectively to various stimuli. The CD28-B7 and tumor necrosis factor receptor (TNFR)-TNF superfamilies contain many of these molecules and were thought to be distinct functioning modules. However, two studies have now provided a new perspective in this already complex area, showing not only a crosstalk between these superfamilies but potentially between co-stimulatory and co-inhibitory receptors.