Predicting the Possible Physiological/Biological Utility of the Hydropersulfide Functional Group Based on Its Chemistry: Similarities Between Hydropersulfides and Selenols
Predicting the Possible Physiological/Biological Utility of the Hydropersulfide Functional Group Based on Its Chemistry: Similarities Between Hydropersulfides and Selenols
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DOI：
10.1089/ars.2020.8079
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发表时间：
2020-03-31
影响因子：
6.6
通讯作者：
Toscano, John P.
中科院分区：
文献类型：
--
作者：
Fukuto, Jon M.;Lin, Joseph;Toscano, John P.
最新进展：在描述过硫化物的化学反应活性/化学性质的同时，已经进行了大量的工作，显然它们的总体化学不同于所有其他生物相关的硫物种(例如，硫醇、二硫化物、磺酸等)。关键问题：预测和最终了解过硫化物的生物功能的一种方法是专注于它们独特的化学，这应该为为什么存在这种独特的功能提供理论基础。有趣的是，RSSH的一些化学性质与硒醇(RSeH)惊人地相似。因此，在推测RSSH物种的可能功能时，考虑硒蛋白的已知功能可能是重要的。未来方向：目前，已经确定了过硫化物和其他生物硫物种之间的许多内在化学差异。然而，是否以及如何利用这些差异来实现特定的生化/生理目标仍有待确定。阐明过硫化物的生物学用途的一个重要方面将是确定其形成和/或生物合成的调节机制，即根据是否可以确定在什么细胞条件下生成过硫化物，可以对其功能/作用进行更有意义的推测。
Recent Advances: A significant amount of work has been performed while delineating the chemical reactivity/chemical properties of hydropersulfides, and it is clear that their overall chemistry is distinct from all other biologically relevant sulfur species (e.g., thiols, disulfides, sulfenic acids, etc.).Critical Issues: One way to predict and ultimately understand the biological functions of hydropersulfides is to focus on their unique chemistry, which should provide the rationale for why this unique functionality is present. Interestingly, some of the chemical properties of RSSH are strikingly similar to those of selenols (RSeH). Therefore, it may be important to consider the known functions of selenoproteins when speculating about the possible functions of RSSH species.Future Directions: Currently, many of the inherent chemical differences between hydropersulfides and other biological sulfur species have been established. It remains to be determined, however, whether and how these differences are utilized to accomplish specific biochemical/physiological goals. A significant aspect of elucidating the biological utility of hydropersulfides will be to determine the mechanisms of regulation of their formation and/or biosynthesis, that is, based on whether it can be determined under what cellular conditions hydropersulfides are made, more meaningful speculation regarding their functions/roles can be developed.