Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disease and pharmacological rescuing of non-motor deficits.
Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disease and pharmacological rescuing of non-motor deficits.
复制标题
DOI：
10.1186/1750-1326-8-14
复制
发表时间：
2013-04-26
影响因子：
15.1
通讯作者：
Salgado AJ
中科院分区：
文献类型：
--
作者：
Carvalho MM;Campos FL;Coimbra B;Pêgo JM;Rodrigues C;Lima R;Rodrigues AJ;Sousa N;Salgado AJ
Parkinson’s disease (PD) is a chronic neurodegenerative condition that is characterized by motor symptoms as a result of dopaminergic degeneration, particularly in the mesostriatal pathway. However, in recent years, a greater number of clinical studies have focused on the emergence of non-motor symptoms in PD patients, as a consequence of damage on the mesolimbic and mesocortical dopaminergic networks, and on their significant impact on the quality of life of PD patients. Herein, we performed a thorough behavioral analysis including motor, emotional and cognitive dimensions, of the unilateral medial forebrain bundle (MFB) 6-hydroxidopamine (6-OHDA)-lesioned model of PD, and further addressed the impact of pharmacological interventions with levodopa and antidepressants on mood dimensions. Based on apomorphine-induced turning behaviour and degree of dopaminergic degeneration, animals submitted to MFB lesions were subdivided in complete and incomplete lesion groups. Importantly, this division also translated into a different severity of motor and exploratory impairments and depressive-like symptoms; in contrast, no deficits in anxiety-like and cognitive behaviors were found in MFB-lesioned animals. Subsequently, we found that the exploratory and the anhedonic behavioural alterations of MFB-lesioned rats can be partially improved with the administration of both levodopa or the antidepressant bupropion, but not paroxetine. Our results suggest that this model is a relevant tool to study the pathophysiology of motor and non-motor symptoms of PD. In addition, the present data shows that pharmacological interventions modulating dopaminergic transmission are also relevant to revert the non-motor behavioral deficits found in the disease.
登录
查看更多内容
影响因子：
2.6
作者：
Czernecki, V;Pillon, B;Dubois, B
通讯作者：
Dubois, B
影响因子：
2.7
作者：
Da Cunha, C;Gevaerd, MS;Canteras, NS
通讯作者：
Canteras, NS
影响因子：
8.6
作者：
Funkiewiez, A;Ardouin, C;Pollak, P
通讯作者：
Pollak, P
影响因子：
5.6
作者：
Chenu, F.;Dailly, E.;Bourin, M.
通讯作者：
Bourin, M.
影响因子：
7.3
作者：
Bredeloux, P.;Dubuc, I.;Costentin, J.
通讯作者：
Costentin, J.