Integrated Flow Processing — Challenges in Continuous Multistep Synthesis
Integrated Flow Processing — Challenges in Continuous Multistep Synthesis
复制标题
集成流处理——连续多步合成的挑战
DOI：
10.1556/1846.2017.00016
复制
发表时间：
2017
影响因子：
2.7
通讯作者：
P. Seeberger
中科院分区：
文献类型：
--
作者：
Bartholomäus Pieber;K. Gilmore;P. Seeberger
由于流动化学技术的采用，有机多步合成的方式正在发生变化，这使得开发制造复杂分子的改进方法成为可能。该技术的模块化性质不仅提供了通过线性流方法获取目标分子的途径，而且还提供了利用单一系统靶向结构核心的方法。这篇透视文章总结了连续多步合成的最新技术，并讨论了该领域的主要挑战和机遇。
The way organic multistep synthesis is performed is changing due to the adoption of flow chemical techniques, which has enabled the development of improved methods to make complex molecules. The modular nature of the technique provides not only access to target molecules via linear flow approaches but also for the targeting of structural cores with single systems. This perspective article summarizes the state of the art of continuous multistep synthesis and discusses the main challenges and opportunities in this area.