Sumoylation and the DNA damage response.
Sumoylation and the DNA damage response.
复制标题
sumoylation和DNA损伤响应。
DOI：
10.3390/biom2030376
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发表时间：
2012-09
期刊：
影响因子：
5.5
通讯作者：
Zhao X
中科院分区：
文献类型：
--
作者：
Cremona CA;Sarangi P;Zhao X
细胞对DNA损伤的反应涉及多条途径，这些途径共同作用，在基因毒性损伤增加的情况下促进生存。这些途径中的蛋白质通常被翻译后修饰，要么被磷酸等小基团修饰，要么被泛素或相扑等蛋白质修饰物修饰。最近发现了更多在损伤条件下以更高水平修饰的相扑底物，这增加了积累的证据，表明相扑在DNA损伤反应中发挥着重要的功能作用。在这里，我们讨论了DNA损伤诱导的总和甲基化的意义，总甲基化对修复蛋白的影响，总甲基化的动态，以及在DNA损伤反应中与其他翻译后修饰的串扰。
The cellular response to DNA damage involves multiple pathways that work together to promote survival in the face of increased genotoxic lesions. Proteins in these pathways are often posttranslationally modified, either by small groups such as phosphate, or by protein modifiers such as ubiquitin or SUMO. The recent discovery of many more SUMO substrates that are modified at higher levels in damage conditions adds weight to the accumulated evidence suggesting that sumoylation plays an important functional role in the DNA damage response. Here we discuss the significance of DNA damage-induced sumoylation, the effects of sumoylation on repair proteins, sumoylation dynamics, and crosstalk with other posttranslational modifications in the DNA damage response.