Measurement of myocardial pH by saturation transfer in man.
Measurement of myocardial pH by saturation transfer in man.
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通过饱和度转移测量人体心肌 pH 值。
DOI：
10.1042/cs090013pc
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发表时间：
1996
影响因子：
3.3
通讯作者：
G. Radda
中科院分区：
文献类型：
--
作者：
A. Blamire;B. Rajagopalan;G. Radda
心肌pH值在动物模型中已被证明是缺血的敏感指标。由于血液2,3-二磷酸甘油酸峰与用于pH测量的P(i)峰重叠，使用31p磁共振波谱在人体体内测量变得复杂。提出了一种结合骨骼肌信号空间预饱和的“饱和传递”方法，该方法可以获得不受2,3- dpg信号污染的心脏频谱，其中可以清晰地观察到细胞内P(i)共振。对一组6名正常受试者的应用发现，细胞内无机磷酸盐峰相对于磷酸肌酸峰的化学位移为4.95+/-0.06。这相当于pH值为7.11+/-0.05。
Myocardial pH has been shown in animal models to be a sensitive indicator of ischemia. In vivo measurement in humans using 31p magnetic resonance spectroscopy is complicated by the overlap of blood 2,3-diphosphoglycerate peaks with the P(i) peak used for pH measurement. A "saturation transfer" method combined with spatial presaturation of skeletal muscle signal is presented which can obtain spectra from the heart free of contamination of 2,3-DPG signal in which intracellular P(i) resonance can be clearly observed. Application to a group of six normal subjects found that the chemical shift of the intracellular inorganic phosphate peak was 4.95+/-0.06 relative to the phosphocreatine peak. This is equivalent to a pH of 7.11+/-0.05.