Morphologic Changes of Dendritic Spines of Striatal Neurons in the Levodopa-Induced Dyskinesia Model
Morphologic Changes of Dendritic Spines of Striatal Neurons in the Levodopa-Induced Dyskinesia Model
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DOI：
10.1002/mds.25826
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发表时间：
2014-03-01
影响因子：
8.6
通讯作者：
Tomiyama, Masahiko
中科院分区：
文献类型：
--
作者：
Nishijima, Haruo;Suzuki, Satoko;Tomiyama, Masahiko
皮质纹状体突触的适应不良可塑性在左旋多巴引起的运动障碍的发生中起着重要作用。最近，研究表明突触可塑性与树突棘的形态变化密切相关。为了评估在左旋多巴诱导的运动障碍模型中投射到苍白球内段或苍白球外段的两种类型纹状体中型多棘神经元的树突棘的形态变化，我们使用了长期接受左旋多巴治疗的6-羟基多巴胺损伤的大鼠。左旋多巴诱导的运动障碍模型的直接通路神经元中的树突棘减少并增大。对未观察到运动障碍的正常大鼠进行相同的左旋多巴治疗，也引起树突棘增大，但直接通路神经元中的树突棘密度并未降低。这些结果表明，直接通路神经元中树突棘的丢失和增大在左旋多巴诱导的运动障碍的发生中起重要作用。 (c) 2014 年国际帕金森与运动障碍学会
Maladaptive plasticity at corticostriatal synapses plays an important role in the development of levodopa-induced dyskinesia. Recently, it has been shown that synaptic plasticity is closely linked to morphologic changes of dendritic spines. To evaluate morphologic changes of dendritic spines of two types of striatal medium spiny neurons, which project to the internal segment of globus pallidus or the external segment of globus pallidus, in the levodopa-induced dyskinesia model, we used 6-hydroxydopamine-lesioned rats chronically treated with levodopa. Dendritic spines were decreased and became enlarged in the direct pathway neurons of the model of levodopa-induced dyskinesia. The same levodopa treatment to normal rats, in which no dyskinesia was observed, also induced enlargement of dendritic spines, but not a decrease in density of spines in the direct pathway neurons. These results suggest that a loss and enlargement of dendritic spines in the direct pathway neurons plays important roles in the development of levodopa-induced dyskinesia. (c) 2014 International Parkinson and Movement Disorder Society