Perirhinal cortex lesions impair tests of object recognition memory but spare novelty detection.
Perirhinal cortex lesions impair tests of object recognition memory but spare novelty detection.
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DOI：
10.1111/ejn.13106
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Aggleton JP
中科院分区：
文献类型：
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作者：
Olarte-Sánchez CM;Amin E;Warburton EC;Aggleton JP
本研究探讨了为什么当两类物体同时出现时，大鼠的嗅周皮层损伤会损害其自发选择新物体而不是熟悉物体的能力。这项研究通过对延迟物体识别记忆的测试，重复了这一标准发现。正如预期的那样，嗅周皮层病变减少了对新刺激和熟悉刺激的探索时间差异。相比之下，当顺序测试对新物体和熟悉物体的优先探索时，即每次试验只由新物体或只由熟悉物体组成时，同一只有嗅周皮层病变的大鼠表现正常。此外，没有迹象表明，如果损伤引起熟悉的新刺激，那么可以预测，周围皮层病变会降低对新物体的探索的总水平。总之，结果表明，在没有周围皮层组织的情况下，大鼠仍然接收到物体新奇的信号，尽管它们可能无法将该信息与适当的物体联系起来。因此，这些大鼠在区分物体新颖性信号来源方面受损，导致在识别的同时选择测试中出现缺陷。
The present study examined why perirhinal cortex lesions in rats impair the spontaneous ability to select novel objects in preference to familiar objects, when both classes of object are presented simultaneously. The study began by repeating this standard finding, using a test of delayed object recognition memory. As expected, the perirhinal cortex lesions reduced the difference in exploration times for novel vs. familiar stimuli. In contrast, the same rats with perirhinal cortex lesions appeared to perform normally when the preferential exploration of novel vs. familiar objects was tested sequentially, i.e. when each trial consisted of only novel or only familiar objects. In addition, there was no indication that the perirhinal cortex lesions reduced total levels of object exploration for novel objects, as would be predicted if the lesions caused novel stimuli to appear familiar. Together, the results show that, in the absence of perirhinal cortex tissue, rats still receive signals of object novelty, although they may fail to link that information to the appropriate object. Consequently, these rats are impaired in discriminating the source of object novelty signals, leading to deficits on simultaneous choice tests of recognition.