Influence of Hemodynamic Factors on Rupture of Intracranial Aneurysms: Patient-Specific 3D Mirror Aneurysms Model Computational Fluid Dynamics Simulation
Influence of Hemodynamic Factors on Rupture of Intracranial Aneurysms: Patient-Specific 3D Mirror Aneurysms Model Computational Fluid Dynamics Simulation
复制标题
血流动力学因素对颅内动脉瘤破裂的影响：患者特异性3D镜像动脉瘤模型计算流体动力学模拟
DOI：
10.3174/ajnr.a2461
复制
发表时间：
2011-08-01
影响因子：
3.5
通讯作者：
Geng, D. Y.
中科院分区：
文献类型：
--
作者：
Lu, G.;Huang, L.;Geng, D. Y.
背景与目的：血流动力学因素在脑动脉瘤破裂中起重要作用。本研究的目的是评估血流动力学因素的影响，破裂的MAN与3D重建模型CFD simulation.Materials和方法：RDSA进行了9对颅内MAN。每对被分为破裂组和未破裂组。比较动脉瘤与载瘤动脉的血流动力学参数。破裂组中动脉瘤区域及其载瘤动脉之间收缩期峰值WSS存在显着差异，分别为6.49 +/- 3.48 Pa和8.78 +/- 3.57 Pa，P = 0.015），但未破裂组中则无差异（即，9.80 +/- 4.12 Pa对比10.17 +/- 7.48 Pa，P = 0.678）。破裂组中低WSS面积占动脉瘤总面积的比例为12.20 +/- 18.08%，未破裂组为3.96 +/- 6.91%;两组之间的差异具有统计学显著性（P = 0.015）。破裂组的OSI为0.0879 +/- 0.0764，显著高于未破裂组（即，0.0183 +/- 0.0191，P = 0.008）。结论：MAN可能是研究与动脉瘤破裂相关的可能原因的有用疾病模型。与未破裂动脉瘤相比，破裂动脉瘤的WSS较载瘤动脉低，低WSS面积占动脉瘤总面积的比例较高，OSI较高。
BACKGROUND AND PURPOSE: Hemodynamics factors play an important role in the rupture of cerebral aneurysms. The purpose of this study was to evaluate the impact of hemodynamic factors on the rupture of the MANs with 3D reconstruction model CFD simulation.MATERIALS AND METHODS: RDSA was performed in 9 pairs of intracranial MANs. Each pair was divided into ruptured and unruptured groups. The hemodynamic factors of the aneurysms and their parent arteries were compared.RESULTS: There was a significant difference in the WSS at peak systole between the regions of the aneurysms and their parent arteries in the ruptured group lie, 6.49 +/- 3.48 Pa versus 8.78 +/- 3.57 Pa, P = .015) but not in the unruptured group (ie, 9.80 +/- 4.12 Pa versus 10.17 +/- 7.48 Pa, P = .678). The proportion of the low WSS area to the whole area of the aneurysms was 12.20 +/- 18.08% in the ruptured group and 3.96 +/- 6.91% in the unruptured group; the difference between the 2 groups was statistically significant (P = .015). The OSI was 0.0879 +/- 0.0764 in the ruptured group, which was significantly higher than that of the unruptured group (ie, 0.0183 +/- 0.0191, P = .008).CONCLUSIONS: MANs may be a useful disease model to investigate possible causes linked to ruptured aneurysms. The ruptured aneurysms manifested lower WSS compared with their parent arteries, a higher proportion of the low WSS area to the whole area of aneurysm, and higher OSI compared with the unruptured aneurysms.