Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction
Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction
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DOI：
10.1161/hc0202.102119
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发表时间：
2002-01-15
期刊：
影响因子：
37.8
通讯作者：
Parodi, O
中科院分区：
文献类型：
--
作者：
Neglia, D;Michelassi, C;Parodi, O
背景-扩张型心肌病有心肌血流量降低的报道。本研究的目的是探讨MBF损伤是否是特发性左心室功能不全患者预后的独立预测因素。（52名男性，平均年龄52 ± 12岁），患有不同程度的特发性LV收缩功能障碍（平均左心室射血分数，0.34+/-0.10;范围，0.07 - 0.49）。34例受试者（51%）在入组时无心力衰竭症状史（NYHA I级）。所有患者均接受了临床和功能评估以及PET研究，以测量静息时和静脉注射潘生丁后的绝对MBF。在平均45+/-37个月的随访中，24例患者发生了主要心脏事件，包括8例心源性死亡和16例心力衰竭的发展或进展。多因素回归分析（考克斯比例风险模型）显示心率（χ（2）11.06，P
Background-Depressed myocardial blood flow (MBF) has been reported in dilated cardiomyopathy. The aim of this study was to investigate whether MBF impairment is an independent predictor of prognosis in patients with idiopathic left ventricular (LV) dysfunction.Methods and Results-Sixty-seven patients (52 male, mean age 52+/-12 years) with different degrees of idiopathic LV systolic dysfunction (average LV ejection fraction, 0.34+/-0.10; range, 0.07 to 0.49) were prospectively enrolled. Thirty-four subjects (51%) had no history of heart failure symptoms at enrollment (NYHA class I). All patients underwent clinical and functional evaluation and a PET study to measure absolute MBF at rest and after intravenous dipyridamole. During a mean follow-up of 45+/-37 months, 24 patients had major cardiac events, including cardiac death in 8 and development or progression of heart failure in 16 patients. Multivariate regression analysis (Cox proportional hazards model) revealed heart rate (chi(2) 11.06, P