Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder
Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder
复制标题
DOI：
10.1038/npp.2014.53
复制
发表时间：
2014-08-01
影响因子：
7.6
通讯作者：
Phan, K. Luan
中科院分区：
文献类型：
--
作者：
Dodhia, Sonam;Hosanagar, Avinash;Phan, K. Luan
广泛性社交焦虑障碍（GSAD）的特征是杏仁核-额叶对威胁和静止的社交信号的连接模式异常。神经肽催产素（OXT）调节焦虑、压力和社会行为。最近的功能性神经影像学研究表明，这些作用是通过OXT对杏仁核反应性和/或杏仁核-额叶连通性的影响来介导的。本研究的目的是检查OXT对GSAD患者和健康对照（hc）的杏仁核-额叶静息状态功能连接（rsFC）的影响。在一项随机、双盲、交叉设计中，18名GSAD和18名HC参与者在静息状态功能磁共振成像前接受鼻腔OXT （24 IU或40.32 mu g）或安慰剂（PBO）。在GSAD患者中，OXT增强了左右杏仁核与吻侧前扣带皮层(ACC)/内侧前额叶皮层（mPFC）的rsFC，这样做逆转了（即“正常化”）相对于PBO中明显的HCs观察到的杏仁核-额叶连通性的减少。GSAD受试者较高的社交焦虑程度与PBO上较低的杏仁核- acc /mPFC连通性相关，较高的社交焦虑程度也与OXT诱导的杏仁核-额叶连通性增强相关。这些发现表明，OXT调节了一个已知的社会威胁处理和情绪调节的神经回路，提示OXT可能在社交焦虑障碍的病理生理和治疗中发挥作用的神经机制。
Generalized social anxiety disorder (GSAD) is characterized by aberrant patterns of amygdala-frontal connectivity to social signals of threat and at rest. The neuropeptide oxytocin (OXT) modulates anxiety, stress, and social behaviors. Recent functional neuroimaging studies suggest that these effects are mediated through OXT's effects on amygdala reactivity and/or amygdala-frontal connectivity. The aim of the current study was to examine OXT's effects on amygdala-frontal resting-state functional connectivity (rsFC) in GSAD patients and healthy controls (HCs). In a randomized, double-blind, cross-over design, 18 GSAD and 18 HC participants received intranasal OXT (24 IU or 40.32 mu g) or placebo (PBO) before resting-state functional magnetic resonance imaging. In individuals with GSAD, OXT enhanced rsFC of the left and right amygdala with rostral anterior cingulate cortex (ACC)/medial prefrontal cortex (mPFC), and in doing so, reversed (ie, 'normalized') the reduced amygdala-frontal connectivity observed relative to HCs evident on PBO. Higher social anxiety severity in GSAD subjects correlated with lower amygdala-ACC/mPFC connectivity on PBO and higher social anxiety also correlated with greater enhancement in amygdala-frontal connectivity induced by OXT. These findings show that OXT modulates a neural circuit known for social threat processing and emotion regulation, suggesting a neural mechanism by which OXT may have a role in the pathophysiology and treatment of social anxiety disorder.