Macroscopic assembly by optical control of zmol-level DNA hybridization
Macroscopic assembly by optical control of zmol-level DNA hybridization
复制标题
zmol级DNA杂交的光学控制宏观组装
DOI：
10.1117/12.2275108
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
S. Tokonami
中科院分区：
文献类型：
--
作者：
T. Iida*;Y. Nishimura;M. Tamura;K. Nishida;S. Ito;S. Tokonami
分子识别的远程加速将为控制各种生物功能开辟一条途径。在这里，我们已经开发了一个新的原则，快速宏观组装的基础上，通过纳米粒子的光诱导分子识别。值得注意的是，作为这一原理的应用，我们已经证明了在几分钟内由zmol级DNA的光诱导杂交引发的亚毫米网络形成。这一发现将用于无荧光标记的快速、高灵敏度的遗传筛查。
Remote acceleration of a molecular recognition will open an avenue for the control of various biological functions. Here, we have developed a new principle for the rapid macroscopic assembly based on the light-induced molecular recognition via nanoparticles. Remarkably, as an application of this principle, we have demonstrated the submillimetre network formation triggered by light-induced hybridization of zmol-level DNA within a few minutes. This finding will be used for the rapid and highly sensitive genetic screening without fluorescent labeling.