Validation of tomographic measurement of cerebral blood volume with C-11-labeled carboxyhemoglobin.
Validation of tomographic measurement of cerebral blood volume with C-11-labeled carboxyhemoglobin.
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发表时间：
1979-04
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通讯作者：
M. Phelps;S. C. Huang;E. Hoffman;D. Kuhl
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作者：
M. Phelps;S. C. Huang;E. Hoffman;D. Kuhl
用/sup 11/CO气体的C-11给药标记的红细胞已用于描绘血液在脑中的分布。然而，迄今为止，这种方法的准确性尚未得到验证。我们用C-11和Cr-51标记的红细胞对四只狗和两只恒河猴的局部脑血容量（CBV）进行了体外测量。这些研究得出CBV/sub C-1/与CBV/sub Cr-11/的比值为1.02 ± 0.03（s.d.）92个样本这些数据的最小二乘拟合显示CBV/sub C-11/ = 1.01 CBV/sub Cr-51/ + 0.037; P远< 0.001。灰质与白色质的CBV比值分别为2.8 ± 0.4（n = 12）和3.1 ± 0.6（n = 8）。使用发射计算机断层扫描（ECT）和/sup 11/CO-RBC进行的体内研究显示，80分钟内横截面CBV和局部（约4 cm/sup 2/）CBV的变异系数分别为+- 2.8%和+- 4.8%。发现平均人CBV为每100 g组织4.2 ± 0.4 cc血液。通过ECT实现了对人类受试者中CBV分布的清晰断层摄影描绘，其提供了对脑血流动力学的这一更多参数的“实时"测量。这些数据表明，通过单次呼吸吸入给予的/sup 11/CO是用于ECT测量CBV的可靠且准确的血液示踪剂。«少
Red blood cells, tagged with C-11 administration of /sup 11/CO gas, have been used to portray the distribution of blood in the brain. To date, however, the accuracy of this approach has not been validated. We have performed in vitro measurements of regional cerebral blood volume (CBV) with red blood cells labeled with C-11 and Cr-51 in four dogs and two rhesus monkeys. These studies yielded a ratio of CBV/sub C-1/ to CBV/sub Cr-11/ of 1.02 +- 0.03 (s.d.) from 92 samples. A least-squares fit to these data showed CBV/sub C-11/ = 1.01 CBV/sub Cr-51/ + 0.037; P much < 0.001. The ratio of CBV in gray matter to that in white matter was 2.8 +- 0.4 (n = 12) and 3.1 +- 0.6 (n = 8). In vivo studies with emission computed tomography (ECT) and /sup 11/CO-RBC gave coefficients of variation of +- 2.8% and +- 4.8% for cross-sectional CBV and regional (approx.4 cm/sup 2/) CBV over an 80-min period. The average human CBV was found to be 4.2 +- 0.4 cc blood per 100 g tissue. Clear tomographic delineation of the distribution of CBV in human subjects is achieved with ECT, which provides a ''live'' measurement of thismore » parameter of cerebral hemodynamics. These data demonstrate that /sup 11/CO administered by single-breath inhalation is a reliable and accurate blood tracer for measurement of CBV with ECT.« less