Single nucleotide polymorphism WRN Leu1074Phe is associated with prostate cancer susceptibility in Chinese subjects.
Single nucleotide polymorphism WRN Leu1074Phe is associated with prostate cancer susceptibility in Chinese subjects.
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发表时间：
2011-10
影响因子：
0.5
通讯作者：
Lei Wang;H. Kaku;P. Huang;Kexin Xu;Kai-Ying Yang;Jiheng Zhang;Ming Li;Liping Xie;Xiao-feng Wang;Akiko Sakai;Masami Watanabe;Y. Nasu;K. Shimizu;H. Kumon;Y. Na
中科院分区：
文献类型：
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作者：
Lei Wang;H. Kaku;P. Huang;Kexin Xu;Kai-Ying Yang;Jiheng Zhang;Ming Li;Liping Xie;Xiao-feng Wang;Akiko Sakai;Masami Watanabe;Y. Nasu;K. Shimizu;H. Kumon;Y. Na
人类DNA修复基因WRN的缺陷是Werner综合征的原因，Werner综合征是一种罕见的常染色体隐性遗传病，特征是过早衰老和易患癌症。这项研究评估了WRN中常见的错义单核苷酸多态WRN Leu1074Phe(Rs1801195)与中国人前列腺癌易感性的关系。研究对象为中国地区3所高校医院的前列腺癌患者147例，男性非肿瘤对照组111例。每名受试者均采集血液样本，采用Snapshot方法对单核苷酸多态WRN Leu1074Phe进行基因分型。结果显示，WRNLeu1074Phe与中国男性前列腺癌风险相关，且TG/GG基因携带者前列腺癌患病率低于TT基因携带者(OR=0.58，95%CI：0.35~0.97，P=0.039)。分层分析显示，确诊年龄为72岁(OR=0.27，95%CI：0.12~0.61，P=0.002)的患者和有局限性疾病的患者(OR=0.36，95%CI：0.19~0.70，P=0.003)与TG/GG基因型有更显著的相关性。然而，在年龄>72岁的亚组和患有晚期疾病的患者中，没有发现统计学上的差异。我们的结论是，DNA修复基因WRN中的Leu1074Phe变异可能在中国人前列腺癌的发病风险中起作用。
Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare autosomal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of WRN Leu1074Phe (rs1801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN Leu1074Phe was genotyped by using a Snapshot assay. The results showed that WRN Leu1074Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR＝0.58, 95%CI:0.35-0.97, p＝0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age ≤ 72 yr (OR＝0.27, 95%CI:0.12-0.61, p＝0.002) and in patients with localized diseases (OR＝0.36, 95%CI:0.19-0.70, p＝0.003). However, no statistically significant difference was found in the subgroup with age ＞72 yr or in patients with advanced diseases. We concluded that the genetic variant Leu1074Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects.