Increased IL-6 and TGF-β1 concentrations in bronchoalveolar lavage fluid associated with thoracic radiotherapy
Increased IL-6 and TGF-β1 concentrations in bronchoalveolar lavage fluid associated with thoracic radiotherapy
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DOI：
10.1016/s0360-3016(03)01614-6
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发表时间：
2004-03-01
影响因子：
7
通讯作者：
Nusgens, B
中科院分区：
文献类型：
--
作者：
Barthelemy-Brichant, N;Bosquée, L;Nusgens, B
用途：为了评估，在肺癌患者中，胸部放疗（RT）对转化生长因子-β（1）（TGF-β（1））和白细胞介素-6（IL-6）的浓度的影响在支气管肺泡灌洗液（BAL）fluid.Methods和材料：11例肺癌患者需要RT作为其治疗的一部分进行了研究。BAL进行双边之前，期间，和1，3，6个月后RT。每次BAL会议之前，患者的状态进行了临床评估，使用肺功能测试和适应性的后期影响正常组织的主观，客观，管理，分析（LENT-SOMA）规模，包括主观和客观的变化。使用国家癌症研究所通用毒性标准对肺炎进行分级。结果：经胸部放射治疗后，照射区BAL液中TGF-β 1和IL-6浓度显著升高，TGF-β 1水平的升高在发生严重肺炎的患者组中更明显。结论：从照射后的肺组织中回收的BAL液中TGF-β 1和IL-6浓度的增加表明，这些细胞因子可能参与了导致人肺组织放射反应的过程。(C)2004年爱思唯尔公司
Purpose: To assess, in lung cancer patients, the effects of thoracic radiotherapy (RT) on the concentrations of transforming growth factor-beta(1) (TGF-beta(1)) and interleukin-6 (IL-6) in the bronchoalveolar lavage (BAL) fluid.Methods and Materials: Eleven patients with lung cancer requiring RT as part of their treatment were studied. BAL was performed bilaterally before, during, and 1, 3, and 6 months after RT. Before each BAL session, the patient's status was assessed clinically using pulmonary function tests and an adapted late effects on normal tissue-subjective, objective, management, analytic (LENT-SOMA) scale, including subjective and objective alterations. The National Cancer Institute Common Toxicity Criteria were used to grade pneumonitis. The TGF-beta(1) and IL-6 levels in the BAL fluid were determined using the Easia kit.Results: The TGF-beta(1) and IL-6 concentrations in the BAL fluid recovered from the irradiated areas were significantly increased by thoracic RT. The increase in TGF-beta(1) levels tended to be greater in the group of patients who developed severe pneumonitis. In the BAL fluid from the nonirradiated areas, the TGF-beta(1) and IL-6 concentrations remained unchanged.Conclusion: The observed increase in TGF-beta(1) and IL-6 concentrations in the BAL fluid recovered from the irradiated lung areas demonstrated that these cytokines may contribute to the process leading to a radiation response in human lung tissue. (C) 2004 Elsevier Inc.