Traditional Chinese Medication Qiliqiangxin attenuates cardiac remodeling after acute myocardial infarction in mice.
Traditional Chinese Medication Qiliqiangxin attenuates cardiac remodeling after acute myocardial infarction in mice.
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中药芪苈强心减轻小鼠急性心肌梗死后心脏重构
DOI：
10.1038/srep08374
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发表时间：
2015-02-11
影响因子：
4.6
通讯作者：
Li X
中科院分区：
文献类型：
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作者：
Tao L;Shen S;Fu S;Fang H;Wang X;Das S;Sluijter JP;Rosenzweig A;Zhou Y;Kong X;Xiao J;Li X
本研究采用多中心随机双盲研究方法，证实中药芪苈强心对心力衰竭患者有保护作用。然而，QLQX是否以及通过何种机制减轻急性心肌梗死（AMI）后的心脏重构仍不清楚。结扎小鼠冠状动脉左前降支建立急性心肌梗死模型。在AMI后的最初3天用QLQX治疗小鼠没有改变梗死面积。然而，QLQX治疗改善了AMI后3周的不良心脏重塑，包括更好地保护心脏功能，减少细胞凋亡和减少纤维化。过氧化物酶体增殖物激活受体-γ（PPARγ）在对照动物AMI后下调，QLQX给药后上调。有趣的是，QLQX处理不改变AKT、SAPK/JNK和ERK的表达。抑制PPARγ可降低QLQX在AMI重构中的有益作用，而激活PPARγ在QLQX存在下未能提供额外的改善，表明PPARγ在AMI后心脏重构期间QLQX的作用中起关键作用。本研究表明，芪连QX通过增加PPARγ水平来减轻AMI后的心脏重塑。总之，QLQX值得进一步研究，作为一种治疗干预，以减轻心肌梗死后的重塑和心力衰竭。
In a multicenter randomized double-blind study we demonstrated that Qiliqiangxin (QLQX), a traditional Chinese medicine, had a protective effect in heart failure patients. However, whether and via which mechanism QLQX attenuates cardiac remodeling after acute myocardial infarction (AMI) is still unclear. AMI was created by ligating the left anterior descending coronary artery in mice. Treating the mice in the initial 3 days after AMI with QLQX did not change infarct size. However, QLQX treatment ameliorated adverse cardiac remodeling 3 weeks after AMI including better preservation of cardiac function, decreased apoptosis and reduced fibrosis. Peroxisome proliferator-activated receptor-γ (PPARγ) was down-regulated in control animals after AMI and up-regulated by QLQX administration. Interestingly, expression of AKT, SAPK/JNK and ERK was not altered by QLQX treatment. Inhibition of PPARγ reduced the beneficial effects of QLQX in AMI remodeling, whereas activation of PPARγ failed to provide additional improvement in the presence of QLQX, suggesting a key role for PPARγ in the effects of QLQX during cardiac remodeling after AMI. This study indicates that QLQX attenuates cardiac remodeling after AMI by increasing PPARγ levels. Taken together, QLQX warrants further investigation as as a therapeutic intervention to mitigate remodeling and heart failure after AMI.