Risk scores for type 2 diabetes can be applied in some populations but not all
Risk scores for type 2 diabetes can be applied in some populations but not all
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DOI：
10.2337/diacare.29.02.06.dc05-0945
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发表时间：
2006-02-01
期刊：
影响因子：
16.2
通讯作者：
Colagiuri, S
中科院分区：
文献类型：
--
作者：
Glümer, C;Vistisen, D;Colagiuri, S
目的-风险评分的基础上的表型特征，以确定个人在高风险有未确诊的糖尿病已开发的高加索人群。已知的危险因素对未确诊的2型糖尿病的影响在不同种族的人群中不同，在高加索人中开发的风险评分可能不适用于其他种族群体。本研究评估了一个风险评分在9个不同种族origin.RESEARCH设计和方法的人口的性能-数据提供的中心从世界各地的DETECT-2项目。该数据库包括基于人群的调查，其中至少有500名没有已知糖尿病的人进行了75克口服葡萄糖耐量试验。到目前为止，52个中心提供了来自34个国家的19万人的数据。在这项分析中，选择了9个代表不同种族和地区背景的横断面研究。评估的风险评分使用了年龄、性别、血压治疗和BMI.RESULTS的信息，该分析包括29，758人，1，805人患有未诊断的糖尿病。风险评分的表现差异很大，敏感性、特异性和需要进一步测试的百分比分别为12 - 57%、72 - 93%和2 - 25%，非高加索人群的表现较差。这种性能的变化与未确诊糖尿病的患病率和风险scores.CONCLUSIONS组件之间的关联差异-一个典型的风险评分在高加索人群中开发的不能适用于其他人群的不同种族起源。
OBJECTIVE - Risk scores based on phenotypic characteristics to identify individuals at high risk of having undiagnosed diabetes have been developed in Caucasian populations. The impact of known risk factors on having undiagnosed type 2 diabetes differs between populations from different ethnic origin, and risk scores developed in Caucasians may not be applicable to other ethnic groups. This study evaluated the performance of one risk score in nine populations of diverse ethnic origin.RESEARCH DESIGN AND METHODS - Data provided by centers from around the world to the DETECT-2 project were used. The database includes population-based surveys with information on at least 500 people without known diabetes having a 75-g oral glucose tolerance test. To date, 52 centers have contributed data on 190,000 individuals from 34 countries. In this analysis, nine cross-sectional studies were selected representing diverse ethnic and regional backgrounds. The risk score assessed uses information on age, sex, blood pressure treatment, and BMI.RESULTS - This analysis included 29,758 individuals, 1,805 individuals had undiagnosed diabetes. The performance of the risk score varied widely, with sensitivity, specificity, and percentage needing further testing ranging between 12 and 57%, 72 and 93%, and 2 and 25%, respectively, with the worse performance in non-Caucasian populations. This variation in performance was related to differences in the association between prevalence of undiagnosed diabetes and components of the risk score.CONCLUSIONS - A typical risk score developed in Caucasian populations cannot be applied to other populations of diverse ethnic origins.