Paracrine systems in the cardioprotective effect of angiotensin-converting enzyme inhibitors on myocardial ischemia reperfusion injury in rats
Paracrine systems in the cardioprotective effect of angiotensin-converting enzyme inhibitors on myocardial ischemia reperfusion injury in rats
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DOI：
10.1161/01.hyp.27.1.7
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发表时间：
1996-01-01
期刊：
影响因子：
8.3
通讯作者：
Carretero, OA
中科院分区：
文献类型：
--
作者：
Liu, YH;Yang, XP;Carretero, OA
在短暂的缺血发作后，溶栓或血管成形术的益处可能会因再灌注损伤而受到限制。血管紧张素转换酶抑制剂保护心脏免受缺血/再灌注损伤，这是一种由激肽介导的作用。我们研究了血管紧张素转换酶抑制剂雷米普利拉对心肌缺血/再灌注的保护作用是否源于激动素刺激前列腺素和/或一氧化氮的释放。结扎Lewis近交系大鼠冠状动脉左前降支30min，再灌流120min。再灌注前立即给予赋形剂、雷米普利拉或血管紧张素II 1型受体拮抗剂氯沙坦治疗。我们检测了激动素受体拮抗剂HoE140、一氧化氮合酶抑制剂N-G-硝基-L-精氨酸甲酯或环氧合酶抑制剂消炎痛是否能阻断雷米普利拉对心肌梗死面积和再灌注性心律失常的影响。对照组中，梗塞面积占危险区域的百分比为79+/-3%；雷米普利拉将其降至49+/-4%(P
After transient episodes of ischemia, benefits of thrombolytic or angioplastic therapy may be limited by reperfusion injury. Angiotensin-converting enzyme inhibitors protect the heart against ischemia/reperfusion injury, an effect mediated by kinins. We examined whether the protective effect of the angiotensin-converting enzyme inhibitor ramiprilat on myocardial ischemia/reperfusion is due to kinin stimulation of prostaglandin and/or nitric oxide release. The left anterior descending coronary artery of Lewis inbred rats was occluded for 30 minutes, followed by 120 minutes of reperfusion. Immediately before reperfusion rats were treated with vehicle, ramiprilat, or the angiotensin II type 1 receptor antagonist losartan. We tested whether pretreatment with the kinin receptor antagonist Hoe 140, the nitric oxide synthase inhibitor N-G-nitro-L-arginine methyl ester, or the cyclooxygenase inhibitor indomethacin blocked the effect of ramiprilat on infarct size and reperfusion arrhythmias. In controls, infarct size as a percentage of the area at risk was 79+/-3%; ramiprilat reduced this to 49+/-4% (P