Expression of epidermal growth factor receptor (EGFR) and downstream-activated peptides in surgically excised non-small-cell lung cancer (NSCLC)
Expression of epidermal growth factor receptor (EGFR) and downstream-activated peptides in surgically excised non-small-cell lung cancer (NSCLC)
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DOI：
10.1016/s0169-5002(03)00225-3
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发表时间：
2003-08-01
期刊：
影响因子：
5.3
通讯作者：
Yoshikawa, J
中科院分区：
文献类型：
--
作者：
Mukohara, T;Kudoh, S;Yoshikawa, J
细胞外信号调节激酶 (ERK)、Akt 以及信号转导子和转录激活子 3 (STAT3) 均位于表皮生长因子受体 (EGFR) 触发的信号转导通路上。本研究的目的是评估这些肽的表达，并将 EGFR 表达水平与非小细胞肺癌 (NSCLC) 中下游激活肽的表达相关联。对总共 60 个标本进行了免疫组织化学研究。 78% 的标本中检测到 EGFR 过度表达，但未发现其与所研究的任何临床病理因素之间存在显着关系。磷酸化 (p)-ERK、p-Akt 和 p-STAT3 表达分别在 28%、53% 和 58% 的标本中观察到，p-Akt 和 p-STAT3 表达与分化良好的肿瘤相关（P 分别 = 0.045 和 0.014）。 60 个样本中有一半表达了两种或三种下游激活肽。 EGFR 表达水平与 p-ERK 和 p-Akt 表达相关（P 分别 = 0.045 和 0.020）。在初步分析中，没有检测到任何肽对无复发生存有影响。总之，各种信号转导途径似乎经常参与 NSCLC，并且 EGFR 表达水平似乎与激活的 ERK 和 Akt 相关，表明受体过度表达在更有效的下游激活中发挥一定作用。 (C) 2003 Elsevier Science Ireland Ltd. 保留所有权利。
Extracellular signal-regulated kinases (ERKs), Akt, and signal transducer and activator of transcription 3 (STAT3) are on signal transduction pathways triggered by epidermal growth factor receptor (EGFR). The purpose of this study was to evaluate the expressions of these peptides and to correlate the level of EGFR expression with downstream-activated peptide expression in non-small-cell lung cancer (NSCLC). A total of 60 specimens were studied by immunohistochemistry. EGFR overexpression was detected in 78% of specimens, but no significant relationship was found between it and any clinicopathological factors investigated. Phosphorylated (p)-ERK, p-Akt, and p-STAT3 expressions were observed in 28, 53, and 58% of specimens, respectively, and p-Akt and p-STAT3 expressions were correlated with well-differentiated tumor (P = 0.045 and 0.014, respectively). Half of the 60 specimens expressed two or three downstream-activated peptides. The level of EGFR expression was associated with expressions of p-ERK and p-Akt (P = 0.045 and 0.020, respectively). In a preliminary analysis, no peptides examined had an impact on relapse-free survival. In summary, various signal transduction pathways appeared frequently to participate in NSCLC, and the level of EGFR expression appeared to correlate with those of activated ERK and Akt, suggesting some role of receptor overexpression in more potent downstream activation. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.