Association of albuminuria and cancer incidence
Association of albuminuria and cancer incidence
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DOI：
10.1681/asn.2007060712
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发表时间：
2008-05-01
影响因子：
13.6
通讯作者：
Jacobsen, Bjarne K.
中科院分区：
文献类型：
--
作者：
Jorgensen, Lone;Heuch, Ivar;Jacobsen, Bjarne K.
蛋白尿与非心血管死亡率相关，可能是细胞因子和其他肿瘤细胞产物引起血管通透性改变的结果。这项基于人群的纵向研究的目的是检查白蛋白与肌酐比值 (ACR) 升高是否与癌症发病率相关。特罗姆瑟研究共追踪了 5425 名没有糖尿病或既往患有癌症的参与者；在 10.3 年的随访期间，有 590 人首次诊断出癌症。即使在调整了年龄、性别、体重指数、体力活动和吸烟情况后，基线时的 ACR 仍与癌症发病率显着相关（P < 0.001）。经过类似调整后，ACR 处于最高五分位的参与者被诊断为膀胱癌和肺癌的可能性分别是 ACR 处于最低五分位的参与者的 8.3 倍和 2.4 倍。结论是，对于没有糖尿病、大量白蛋白尿或既往癌症史的个体来说，白蛋白尿与癌症发病率相关，并且它可能会给不同类型的癌症带来不同程度的风险。
Albuminuria, which is associated with noncardiovascular mortality, might be a result of altered vascular permeability caused by cytokines and other tumor cell products. The aim of this population-based, longitudinal study was to examine whether elevated albumin-to-creatinine ratio (ACR) is associated with cancer incidence. A total of 5425 participants without diabetes or previous cancer in the Tromso Study were followed; 590 had a first diagnosis of cancer during 10.3 yr of follow-up. The ACR at baseline significantly correlated with the incidence of cancer, even after adjustment for age, gender, body mass index, physical activity, and smoking (P < 0.001). Participants with ACR in the highest quintile were 8.3-and 2.4-fold more likely to receive a diagnosis of bladder cancer and lung cancer, respectively, compared with those with ACR in the lowest quintile after similar adjustments. It is concluded that albuminuria is associated with cancer incidence in individuals without a history of diabetes, macroalbuminuria, or previous cancer and that it might confer risks of varying magnitude for different types of cancer.