GDF-15 is associated with thrombus burden in patients with deep venous thrombosis
GDF-15 is associated with thrombus burden in patients with deep venous thrombosis
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DOI：
10.1016/j.thromres.2020.01.022
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发表时间：
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期刊：
影响因子：
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通讯作者：
Miao Yu
中科院分区：
文献类型：
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作者：
Wei Liang;Fen Wei;Chao Yang;Feng Xie;Xin-Xin Shuai;Ming Wang;Miao Yu
Introduction: Growth differentiation factor-15 (GDF-15) has been identified as a predictor in.cardiovascular diseases and acute pulmonary embolism. However, the association of GDF-15 and.deep venous thrombosis (DVT) remains unclear. This study aimed to investigate levels of GDF-15.in patients with DVT, and determine its association with the thrombus burden..Materials and Methods: 72 newly diagnosed DVT patients and 30 healthy volunteers were.enrolled, and the levels of plasma GDF-15 were detected. To explore the relationship between.GDF-15 and thrombus severity, we analyzed the thrombus burden and the association with.pulmonary embolism of DVT patients. In vitro, the effect of GDF-15 on platelet aggregation and.thrombin/antithrombin activity were investigated..Results: We found that the mean levels of plasma GDF-15 in DVT patients were significantly.higher than those in healthy controls (1448.78 ± 61.98 pg/ml VS 805.70 ± 112.95 pg/ml, P<0.001)..Furthermore, GDF-15 showed an increase with more venous segments with thrombus (P<0.001),.and the patients with higher levels of GDF-15 and more thrombus segments showed higher scores.of Wells-PE and Geneva and increased incidence of pulmonary embolism (P<0.05). In vitro, we.confirmed that GDF-15 significantly reduced platelet aggregation induced by ADP and the effect.was concentration-dependent (P<0.001). However, GDF-15 showed no direct effect on thrombin.and anti-thrombin activity..Conclusions: Increased GDF-15 level was associated with more thrombus severity of DVT.patients and GDF-15 could inhibit platelet aggregation induced by ADP in vitro. These findings.suggest that GDF-15 might not only be an indicator for thrombus severity but also be a potential.treatment target in DVT
