Bombesin-like peptides and their receptors: recent findings in pharmacology and physiology
Bombesin-like peptides and their receptors: recent findings in pharmacology and physiology
复制标题
铃蟾肽样肽及其受体：药理学和生理学的最新发现
DOI：
10.1097/med.0000000000000126
复制
发表时间：
2015-02-01
影响因子：
3.2
通讯作者：
Qin, Xiaoqun
中科院分区：
文献类型：
--
作者：
Guo, Man;Qu, Xiangping;Qin, Xiaoqun
综述目的介绍蛙皮素样肽及其受体在药理学和生理学方面的研究进展，并设计了几种新的蛙皮素衍生的放射性或非放射性化合物，用于诊断和治疗过度表达蛙皮素受体的肿瘤。胃泌素释放肽受体和神经介肽B受体的激活都能引起膜去极化和兴奋脑内神经元。蛙皮素受体亚型3在肥胖和2型糖尿病患者的肌细胞和心肌细胞中表达下调，并研究了其在葡萄糖稳态中的相关细胞信号传导事件。近年来，蛙皮素受体在不同类型的恶性肿瘤中的激活所引发的分子事件的研究不断深入，为更好地理解蛙皮素受体异常表达在肿瘤中的生物学作用提供了新的线索。在小细胞肺癌中发现了胃泌素释放肽受体细胞信号通路和Sonic hedgehog通路之间的新的交叉作用。综述越来越多的证据表明蛙皮素样肽及其受体在生理状态和疾病中起着重要作用。更特异、更安全的肿瘤靶向蛙皮素衍生物正被开发用于肿瘤诊断和治疗。
Purpose of reviewTo highlight the research progress of roles of bombesin-like peptides and their receptors in pharmacology and physiology.Recent findingsSeveral new bombesin-derived radioactive or nonradioactive compounds were designed for the diagnosis and therapy of tumors that are overexpressing bombesin receptors. Both gastrin-releasing peptide receptor and neuromedin B receptor activation were shown to induce membrane depolarization and excite neurons in brain. Bombesin receptor subtype-3 was found to be downregulated in the muscle cells and myocytes from obese and type 2 diabetes patients, and its relevant cell signaling events in glucose homeostasis were also investigated. The molecular events triggered by bombesin receptors activation in different types of malignancies is being explored recently and new clues were provided for a better understanding of the biological roles of abnormal expression of bombesin receptors in tumors. Novel cross-talk between gastrin-releasing peptide receptor cell signaling and Sonic hedgehog pathways was identified in small-cell lung carcinoma.SummaryIncreasing evidence shows bombesin-like peptides and their receptors play important roles in both physiological state and diseases. More specific and safe tumor targeting Bombesin derivatives are being developed for tumor diagnosis and therapy.