Development and distribution of pathologic lesions are related to immune status and tissue deposition of human granulocytic ehrlichiosis agent-infected cells in a murine model system
Development and distribution of pathologic lesions are related to immune status and tissue deposition of human granulocytic ehrlichiosis agent-infected cells in a murine model system
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DOI：
10.1086/314902
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发表时间：
1999-08-01
影响因子：
6.4
通讯作者：
Dumler, JS
中科院分区：
文献类型：
--
作者：
Bunnell, JE;Trigiani, ER;Dumler, JS
为了评价人类粒细胞埃立克体病（HGE）的小鼠模型系统中的病理学和免疫状态的作用，用HGE试剂感染C3 H/HeJ、C3 H-SCID和白足鼠（Peromyscus leucopus）小鼠。所有小鼠均保持健康。第14天后，在P. leucopus和C3 H/HeJ小鼠中未检测到埃立克体血症，但在CSH-SCID小鼠中在第14天至第90天之间增加。在第21天及以后检查的组织中，免疫活性小鼠中很少检测到感染，但所有C3 H-SCID小鼠均存在感染，包括肺内皮细胞和肝单核细胞聚集体。HGE试剂在造血组织中的成熟和未成熟髓样细胞中被证明，很少在肺和肝病变中有感染细胞沉积。免疫功能低下小鼠中的HGE因子感染进展缓慢，具有较高的感染负荷和更多的组织病理学，并且是持续性的。HGE的小鼠模型可能有助于评估病理损伤、传播和持续性。
To evaluate pathology and the role of immune status in a murine model system of human granulocytic ehrlichiosis (HGE), C3H/HeJ, C3H-SCID, and Peromyscus leucopus mice were infected with an HGE agent. All mice remained healthy. Ehrlichemia was not detected after day 14 in P. leucopus and C3H/HeJ mice but increased between days 14 and 90 in CSH-SCID mice. In tissues examined at day 21 and later, infection was rarely detected in immunocompetent mice but was present in all C3H-SCID mice and included pulmonary endothelialitis and hepatic mononuclear cell aggregates with apoptoses. HGE agent was demonstrated in mature and immature myeloid cells in hematopoietic tissues and infrequently in lung and liver lesions with deposition of infected cells. HGE agent infection in immunocompromised mice progresses slowly, has a higher infectious burden and more tissue pathology and is persistent. A murine model for HGE may be useful to assess pathologic lesions, transmission, and persistence.