Characterization and optimization of a rapid, automated 3D-printed cone spray ionization-mass spectrometry (3D-PCSI-MS) methodology
Characterization and optimization of a rapid, automated 3D-printed cone spray ionization-mass spectrometry (3D-PCSI-MS) methodology
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DOI：
10.1016/j.ijms.2021.116781
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发表时间：
2022-02-14
影响因子：
1.8
通讯作者：
Fedick, Patrick W.
中科院分区：
文献类型：
--
作者：
Brown, Hilary M.;McDaniel, Trevor J.;Fedick, Patrick W.
3D打印锥形喷雾电离质谱（3D-PCSI-MS）是一种环境电离技术，用于快速原位分析固体基质中的散装固体和痕量分析物。可重复制造的3D打印圆锥体用作收集装置、提取室和基于喷雾的电离源。在此，我们讨论了基于萃取和喷涂溶剂与导电塑料类型的兼容性、所选材料的强度以及圆锥几何形状的优点和缺点的材料选择。还记录了打印的简易性和可重现生产所需的参数。为了提高样品吞吐量、可重复定位以及自动溶剂输送和分析，利用商用现货（COTS）部件和定制3D打印件开发了自动进样器。最后，通过3D-PCSI-MS在现场便携式质谱仪上的自动采样的应用被证明用于环境，国防和法医应用。(c)2021由爱思唯尔公司出版
3D-printed cone spray ionization-mass spectrometry (3D-PCSI-MS) is an ambient ionization technique developed for the rapid, in-situ analysis of bulk solids and trace analytes within solid matrices. A reproducibly fabricated 3D-printed cone is used as the collection device, the extraction chamber, and the spray-based ionization source. Herein, we discuss the material selection based on the extraction and spray solvent compatibility with conductive plastic types, the strength of the selected material, and the advantages and disadvantages of the cone geometry. The ease of printing and the required parameters for reproducible manufacturing is also documented. To allow for improved sample throughput, repro-ducible positioning, and automated solvent delivery and analysis, an autosampler was developed from commercial-off-the-shelf (COTS) parts and custom 3D-printed pieces. Finally, the application of this automated sampling via 3D-PCSI-MS on a field portable mass spectrometer was demonstrated for environmental, defense, and forensic applications. (c) 2021 Published by Elsevier B.V.