Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular-Subventricular Zone
Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular-Subventricular Zone
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DOI：
10.1007/s11064-015-1766-z
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发表时间：
2016-02-01
影响因子：
4.4
通讯作者：
Sawamoto, Kazunobu
中科院分区：
文献类型：
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作者：
Hirota, Yuki;Sawada, Masato;Sawamoto, Kazunobu
在许多动物物种中，新神经元的产生（神经发生）贯穿整个生命周期，发生在称为心室-心室下区 (V-SVZ) 的特殊生发区域。在这个区域，神经干细胞进行自我更新并产生神经祖细胞和新的神经元。在嗅觉系统中，新的神经元向嗅球方向迁移，在那里分化成成熟的中间神经元。 V-SVZ 衍生的新神经元也可以迁移到脑损伤部位，在那里它们有助于神经再生。最近的研究表明，Wnt 信号通路的两个主要分支，Wnt/β-连环蛋白和 Wnt/平面细胞极性通路，在成体神经发生的各个方面发挥着重要作用。在这里，我们回顾了生理和病理条件下 Wnt 信号介导的 V-SVZ 成人神经发生的调节。
In many animal species, the production of new neurons (neurogenesis) occurs throughout life, in a specialized germinal region called the ventricular-subventricular zone (V-SVZ). In this region, neural stem cells undergo self-renewal and generate neural progenitor cells and new neurons. In the olfactory system, the new neurons migrate rostrally toward the olfactory bulb, where they differentiate into mature interneurons. V-SVZ-derived new neurons can also migrate toward sites of brain injury, where they contribute to neural regeneration. Recent studies indicate that two major branches of the Wnt signaling pathway, the Wnt/beta-catenin and Wnt/planar cell polarity pathways, play essential roles in various facets of adult neurogenesis. Here, we review the Wnt signaling-mediated regulation of adult neurogenesis in the V-SVZ under physiological and pathological conditions.