Preventive effects of Chlorella on cognitive decline in age-dependent dementia model mice
Preventive effects of Chlorella on cognitive decline in age-dependent dementia model mice
复制标题
DOI：
10.1016/j.neulet.2009.08.044
复制
发表时间：
2009-10-30
影响因子：
2.5
通讯作者：
Ohta, Shigeo
中科院分区：
文献类型：
--
作者：
Nakashima, Yuya;Ohsawa, Ikuroh;Ohta, Shigeo
氧化应激是年龄依赖性记忆丧失和认知能力下降的主要原因之一。细胞毒性醛类来自脂质过氧化物，它们的积累可能是年龄依赖性神经退行性疾病（包括阿尔茨海默病）的原因。由于乙醛脱氢酶解毒这种醛，我们构建了转基因小鼠与线粒体乙醛脱氢酶2（ALDH 2）活性缺陷（DAL 101小鼠）作为年龄依赖性痴呆模型。这种模型动物是由持续的氧化应激与年龄相关的进展，因此使我们能够研究预防痴呆症的食物。由于小球藻，一种藻类，具有各种抗氧化作用，我们调查了小球藻是否有可能预防年龄依赖性认知障碍。我们喂小球藻给DAL 101小鼠，并使用Morris水迷宫和物体识别测试研究其对氧化应激和认知衰退进展的影响。这两种方法都表明，小球藻的饮食倾向于减少氧化应激，并显着防止认知能力的下降。此外，食用小球藻减少了DAL101脑中活化的星形胶质细胞的数量。这些发现表明，长期食用小球藻有可能防止认知障碍的进展。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Oxidative stress is one of the major causes of age-dependent memory loss and cognitive decline. Cytotoxic aldehydes are derived from lipid peroxides and their accumulation maybe responsible for age-dependent neurodegeneration, including Alzheimer's disease. Since aldehyde dehydrogenases detoxify such aldehydes, we constructed transgenic mice with mitochondrial aldehyde dehydrogenase 2 (ALDH2) activity deficiency (DAL101 mice) as an age-dependent dementia model. This model animal is age-dependently progressed by persistent oxidative stress, and thus enables us to investigate foods that prevent dementia. Since Chlorella, a kind of alga, exhibits various anti-oxidative effects, we investigated whether Chlorella has the potential to prevent age-dependent cognitive impairment. We fed Chlorella to DAL101 mice and investigated its effects on oxidative stress and the progression of cognitive decline using the Morris water-maze and object recognition tests. The diet with Chlorella tended to reduce oxidative stress and significantly prevented the decline of cognitive ability, as shown by both methods. Moreover, consumption of Chlorella decreased the number of activated astrocytes in the DAL101 brain. These findings suggest that the prolonged consumption of Chlorella has the potential to prevent the progression of cognitive impairment. (C) 2009 Elsevier Ireland Ltd. All rights reserved.