Aspirin and lung cancer in women
Aspirin and lung cancer in women
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DOI：
10.1038/sj.bjc.6600370
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发表时间：
2002-07-01
影响因子：
8.8
通讯作者：
Shore, RE
中科院分区：
文献类型：
--
作者：
Akhmedkhanov, A;Toniolo, P;Shore, RE
在纽约大学妇女健康研究中，一项病例对照研究检查了阿司匹林使用与妇女肺癌风险之间的关系，该研究是纽约的一项大型队列研究。病例受试者是所有在入组时和1994-1996年随访期间提供阿司匹林使用信息的81例肺癌病例。每例病例随机选择10名对照，这些对照是从年龄、绝经状态、入组日期和随访日期与病例匹配的研究参与者中随机选择的。相对于不使用阿司匹林，在调整吸烟和教育后，报告每周使用阿司匹林3次或以上至少6个月的受试者中肺癌（所有组织学亚型合并）的比值比为0.66（95%置信区间0.34-1.28）。在仅限于非小细胞肺癌的分析中观察到更强的负相关（校正比值比0.39，95%置信区间0.16-0.96）。这些结果表明，定期服用阿司匹林可能与女性肺癌风险呈负相关，特别是非小细胞亚型。(C)2002年英国癌症研究。
The association between aspirin use and lung cancer risk in women was examined in a case-control study nested in the New York University Women's Health Study, a large cohort in New York. Case subjects were all the 8 l incident lung cancer cases who had provided information about aspirin use at enrollment and during the 1994-1996 follow up. Ten controls per case were randomly selected from among study participants who matched a case by age, menopausal status, and dates of enrollment and follow-up. Relative to no aspirin use, the odds ratio for lung cancer (all histological sub-types combined) among subjects who reported aspirin use three or more times per week for at least 6 months was 0.66 (95% confidence interval 0.34-1.28), after adjustment for smoking and education. A stronger inverse association was observed in analyses restricted to non-small cell lung cancer (adjusted odds ratio 0.39, 95% confidence interval 0.16-0.96). These results suggest that regular aspirin use might be inversely associated with risk of lung cancer in women, particularly the non-small cell sub-type. (C) 2002 Cancer Research UK.