Cor a 14 is the superior serological marker for hazelnut allergy in children, independent of concomitant peanut allergy
Cor a 14 is the superior serological marker for hazelnut allergy in children, independent of concomitant peanut allergy
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DOI：
10.1111/all.12820
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发表时间：
2016-04-01
期刊：
影响因子：
12.4
通讯作者：
Bindslev-Jensen, C.
中科院分区：
文献类型：
--
作者：
Eller, E.;Mortz, C. G.;Bindslev-Jensen, C.
背景资料：榛子是树坚果过敏的最常见原因，但高达一半的榛子过敏儿童还患有花生过敏。我们的目的是确定最有前途的血清学标志物（Cor a 9和Cor a 14）的诊断价值，并解决伴随花生过敏和PR 10 sensitivity.Method的影响：我们包括155名儿童怀疑榛子过敏和挑战，根据指南。通过攻毒证实或排除了对花生的伴随过敏。皮肤点刺试验，s-IgE和CRD榛子，花生，PR 10和LPT蛋白家族使用ImmunoCAP.Results：六十五名儿童有一个积极的榛子挑战，和60%的这些也有伴随花生过敏。对榛子过敏的儿童对Cor a 9和Cor a 14致敏;对花生过敏的儿童对Ara h 2致敏。PR 10蛋白质成分的致敏性在所有纳入儿童中的45%中观察到，与花生或榛子过敏无关。Cor a 14的IgE临界值>0.72 kU/L诊断正确率为87%，使Cor a 14成为上级血清学标志物。结论：花生过敏在榛子过敏儿童中较为常见，但花生过敏对榛子过敏的诊断价值及判断标准无影响。我们发现了三个独立的和良好的特点血清型;榛子过敏的儿童致敏Cor A 14，花生过敏的儿童致敏Ara H 2，并独立于此的儿童致敏桦树花粉（Bet V 1）。
Background: Hazelnut is the most frequent cause of tree nut allergy, but up to half of all children with hazelnut allergy additionally suffer from peanut allergy. Our aim was to identify diagnostic values of the most promising serological markers (Cor a 9 and Cor a 14) and to address the influence of concomitant peanut allergy and PR10 sensitization.Method: We included 155 children suspected of hazelnut allergy and challenged according to the guidelines. Concomitant allergy to peanuts was verified or ruled out by challenge. Skin prick test, s-IgE and CRD to hazelnut, peanut, PR10 and LPT protein families were measured using ImmunoCAP.Results: Sixty-five children had a positive hazelnut challenge, and 60% of these also had a concomitant peanut allergy. Children allergic to hazelnut were sensitized to Cor a 9 and Cor a 14; peanut-allergic children were sensitized to Ara h 2. Sensitization to PR10 protein components was seen in 45% of all included children, irrelevant to allergy to peanut or hazelnut. A cut-off >0.72 kU/L of IgE towards Cor a 14 diagnosed 87% correctly, making Cor a 14 the superior serology marker. However, nine hazelnut-allergic children were primarily sensitized to Cor a 9.Conclusion: Concomitant peanut allergy is common in hazelnut-allergic children, but decision points as well as diagnostic values for Cor a 14 are not affected. We found three independent and well-characterized serotypes; hazelnut-allergic children were sensitized to Cor a 14, peanut-allergic children were sensitized to Ara h 2, and independently of this were children sensitized to birch pollen (Bet v 1).