Aminohalogenation of Electron‐Deficient Olefins Promoted by Hypervalent Iodine Compounds
Aminohalogenation of Electron‐Deficient Olefins Promoted by Hypervalent Iodine Compounds
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DOI：
10.1002/ejoc.200800842
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发表时间：
2008-12
影响因子：
2.8
通讯作者：
Xue‐Liang Wu;Guan‐Wu Wang
中科院分区：
文献类型：
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作者：
Xue‐Liang Wu;Guan‐Wu Wang
用高价碘化合物促进的缺电子烯烃的氨卤化反应是一种有效而实用的方法。还考察了不同羧基和磺酸配体的高价碘化合物的催化效率，其中二乙酰氧基碘的催化活性最高。一系列底物，包括α，β-不饱和酮、肉桂酸酯和肉桂酸酯，在所使用的条件下是可以耐受的，并且以良好的产率和极好的非对映选择性进行了氨氯化/溴化。
An efficient and practical procedure for the aminohalogenation of electron-deficient olefins promoted by hypervalent iodine compounds has been demonstrated. The catalytic efficiency of various hypervalent iodine compounds with different carboxylic and sulfonic ligands has also been investigated and of these (diacetoxyiodo)benzene exhibited the highest activity. A series of substrates, including α,β-unsaturated ketones, cinnamates, and cinnamides, were tolerable under the conditions employed and were aminochlorinated/-brominated in good yields and with excellent diastereoselectivities.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)