Hyperactivated motility in sperm.
Hyperactivated motility in sperm.
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DOI：
10.1002/j.1939-4640.1996.tb01797.x
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发表时间：
1996-07
影响因子：
--
通讯作者：
Susan S. Suarez
中科院分区：
文献类型：
--
作者：
Susan S. Suarez
超激活的功能可能会结合在一起，以创建以下场景。进入输卵管的精子与粘膜上皮结合。接近排卵时，过度活跃有助于它们脱离上皮，逃离粘膜袋，并通过输卵管粘液移动。当精子到达壶腹时，方向的频繁变化可能会使他们遇到积云。然后，过度激活帮助它们穿透卵丘基质，并在顶体反应后，进入透明带。排卵期输卵管或卵泡液中的一个或多个因素可能通过提高精子中的细胞内钙水平来诱导过度激活。对过度激活调节机制的了解可能被用来开发新的精液样本生育能力的临床测试。
The functions of hyperactivation may fit together to create the following scenario. Sperm that enter the oviduct bind to the mucosal epithelium. Near the time of ovulation, hyperactivation helps them to detach from the epithelium, escape mucosal pockets, and move through oviductal mucus. As sperm reach the ampulla, frequent changes in direction may enable them to encounter the cumulus mass. Then, hyperactivation assists them in penetrating the cumulus matrix and, after acrosome reacting, the zona pellucida. A factor or factors in the periovulatory oviduct or follicular fluid may induce hyperactivation by raising intracellular calcium levels in sperm. Knowledge of mechanisms regulating hyperactivation may be used to develop new clinical tests for fertility of semen samples.