Contribution of RGD sequence to neuronal migration in developing cerebral cortex.
Contribution of RGD sequence to neuronal migration in developing cerebral cortex.
复制标题
RGD 序列对发育中大脑皮层神经元迁移的贡献。
DOI：
10.1097/00001756-199411000-00014
复制
发表时间：
1994
期刊：
影响因子：
1.7
通讯作者：
H. Otani
中科院分区：
文献类型：
--
作者：
T. Hatta;O. Tanaka;H. Otani
The RGD sequence (Arg-Gly-Asp) is known to bind integrins and the synthetic RGD tripeptide inhibits cell adhesion and migration of cultured neuronal cells. However, it is not known whether migration of neuronal precursors in vivo during the cortical histogenesis of the mammalian telencephalon depends on the RGD sequence. To examine this possibility, the RGD peptide was injected into the telencephalic vesicle of mouse embryos. A hypoplastic cortical plate was induced and histological analysis and BrdU-immunohistochemistry revealed that the RGD sequence is involved in neuronal migration and proliferation in the telencephalon during formation of the cortical plate.
