Cranial bone defects: current and future strategies
Cranial bone defects: current and future strategies
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DOI：
10.3171/2010.9.focus10201
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发表时间：
2010-12-01
影响因子：
4.1
通讯作者：
Warren, Stephen M.
中科院分区：
文献类型：
--
作者：
Szpalski, Caroline;Barr, Jason;Warren, Stephen M.
颅颌面骨骼的骨缺陷仍然是一个主要且具有挑战性的健康问题。几个世纪以来，外科医生一直在尝试使用自体移植物、同种异体移植物甚至异种移植物来恢复功能和美观，但没有取得完全令人满意的结果。因此，过去几十年来，医生、科学家和工程师一直在努力开发新技术来改善骨骼生长和骨骼愈合。在这篇综述中，作者总结了当前动物模型的优点和局限性；描述当前用作支架、基于细胞和基于蛋白质的疗法的材料；最后强调未来研究的领域。本次综述的目的是强调目前正在开发的用于修复颅骨缺陷的主要基于支架、细胞和蛋白质的临床前工具。 （DOI：10.3171/2010.9.FOCUS10201）
Bony defects in the craniomaxillofacial skeleton remain a major and challenging health concern. Surgeons have been trying for centuries to restore functionality and aesthetic appearance using autografts, allografts, and even xenografts without entirely satisfactory results. As a result, physicians, scientists, and engineers have been trying for the past few decades to develop new techniques to improve bone growth and bone healing. In this review, the authors summarize the advantages and limitations of current animal models; describe current materials used as scaffolds, cell-based, and protein-based therapies; and lastly highlight areas for future investigation. The purpose of this review is to highlight the major scaffold-, cell-, and protein-based preclinical tools that are currently being developed to repair cranial defects. (DOI: 10.3171/2010.9.FOCUS10201)