The alpha2-adrenergic receptor gene and body fat content and distribution:: The HERITAGE Family Study
The alpha2-adrenergic receptor gene and body fat content and distribution:: The HERITAGE Family Study
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DOI：
10.1007/bf03402078
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发表时间：
2002-02-01
影响因子：
5.7
通讯作者：
Bouchard, C
中科院分区：
文献类型：
--
作者：
Garenc, C;Pérusse, L;Bouchard, C
背景：在调节脂质动员的肾上腺素能受体亚型中，α2-肾上腺素能受体参与抑制脂肪组织中的脂肪酸动员。 C-1291G 多态性位于 α2-肾上腺素受体基因 (ADRA2A)，但尚未报道与身体脂肪积累相关。 材料和方法：体重指数 (BMI)、脂肪量 (FAT)、体脂百分比 (%FAT)、躯干与四肢皮褶比 (TER)、八皮褶总和 (SF8) 以及腹部皮下 (ASF)、内脏 (AVF) 和通过 CT 扫描评估的总 (ATF) 脂肪面积已在参加 HERITAGE 家庭研究的成年久坐白人 (n = 503) 和黑人 (n = 276) 受试者中进行了测量。使用 ANCOVA 在每个种族的男性和女性中分别测试 C-1291G 多态性与每种表型之间的关联，除了 BMI 对 TER 的影响以及 FAT 对 AVF、ASF 和 ATF 的影响外，还以年龄作为协变量。结果：ADRA2A C-1291G 多态性的等位基因频率在种族之间存在差异。在白人受试者中没有观察到相关性，除了多态性的中等影响（占女性 AVF 和 ATF 变异的不到 11%）之外。然而，在黑人受试者中，G-1291 等位基因被发现与男性 TER 的增加有关（多态性导致 3.8% 的变异），而在黑人女性中，它与 TER (2.9%) 和 AVF (2.5%) 的减少有关。结论：这些结果表明，ADRA2A 基因在决定腹部区域储存脂肪的倾向方面发挥着作用，与全身脂肪无关。
Background: Among adrenergic receptor subtypes that regulate lipid mobilization, the alpha2-adrenergic receptor is involved in the inhibition of fatty acid mobilization from adipose tissue. A C-1291G polymorphism is located in the alpha2-adrenergic receptor gene (ADRA2A) but no association with body fat accumulation has been reported yet.Materials and Methods: Body mass index (BMI), fat mass (FAT), percentage body fat (%FAT), trunk-to-extremity skinfold ratio (TER), sum of eight skinfolds (SF8), and abdominal subcutaneous (ASF), visceral (AVF), and total (ATF) fat areas assessed by CT scan have been measured in adult sedentary white (n = 503) and black (n = 276) subjects participating in the HERITAGE Family Study. Association between the C-1291G polymorphism and each phenotype was tested separately in men and women of each race using ANCOVA with the effects of age as covariate in addition to the effects of BMI for TER and of FAT for AVF, ASF, and ATF.Results: The allele frequencies of the ADRA2A C-1291G polymorphism differed between races. No association was observed in white subjects, except for a moderate effect of the polymorphism accounting for less than 11% of the variance in AVF and ATF in women. in black subjects, however, the G-1291 allele was found to be associated with an increase of TER in men (3.8% of variance accounted for by the polymorphism), while in black women it was associated with a decrease in TER (2.9%) and in AVF (2.5%).Conclusion: These results suggest a role for the ADRA2A gene in determining the propensity to store fat in the abdominal area, independently of total body fatness.