Acceptance of a COVID-19 Vaccine in Southeast Asia: A Cross-Sectional Study in Indonesia
Acceptance of a COVID-19 Vaccine in Southeast Asia: A Cross-Sectional Study in Indonesia
复制标题
DOI：
10.3389/fpubh.2020.00381
复制
发表时间：
2020-07-14
影响因子：
5.2
通讯作者：
Mudatsir, Mudatsir
中科院分区：
文献类型：
--
作者：
Harapan, Harapan;Wagner, Abram L.;Mudatsir, Mudatsir
引言：为应对2019冠状病毒病（COVID-19）大流行，几种候选疫苗正在进行临床试验。这项研究的目的是评估50%或95%有效的COVID-19疫苗在东南亚可用时在印度尼西亚普通人群中的接受程度。方法：在2020年3月25日至4月6日期间进行了横断面在线调查。参与者被问及是否愿意接受有效率为95%或50%的免费疫苗。使用逻辑回归模型，我们评估了社会人口特征、COVID-19信息暴露或感知感染风险与接受假设的COVID-19疫苗之间的关联。结果：在1，359名受访者中，93.3%的受访者（1，268/1，359）希望接种95%有效的疫苗，但对于50%有效的疫苗，这一接受度下降至67.0%（911/1，359）。对于95%有效的疫苗，作为医护人员和具有较高的COVID-19感染风险与较高的接受度相关，调整后的比值比（aOR）分别为：2.01; 95%CI：1.01，4.00和aOR：2.21; 95%CI：1.07，4.59;与公务员相比，退休与接受度较低相关（或：0.15; 95%可信区间：0.04，0.63）。对于50%有效的疫苗，作为一名医护人员也与更大的接受度相关，aOR：1.57; 95%CI：1.12，2.20。结论：COVID-19疫苗的接受程度受到疫苗基线有效性的高度影响。使一般人群做好接受效力相对较低的疫苗的准备可能是困难的。
Introduction:Several vaccine candidates are being clinically tested in response to the 2019 coronavirus disease (COVID-19) pandemic. This study was conducted to assess the acceptance of a 50 or 95% effective COVID-19 vaccine, when it becomes available in southeast Asia, among the general population in Indonesia. Methods:A cross-sectional online survey was conducted between March 25 and April 6, 2020. Participants were asked if they would accept a free vaccine which was 95 or 50% effective. Using a logistic regression model, we assessed the associations between sociodemographic characteristics, exposure to COVID-19 information, or perceived risk of infection with acceptance of a hypothetical COVID-19 vaccine. Results:Among 1,359 respondents, 93.3% of respondents (1,268/1,359) would like to be vaccinated for a 95% effective vaccine, but this acceptance decreased to 67.0% (911/1,359) for a vaccine with 50% effectiveness. For a 95% effective vaccine, being a healthcare worker and having a higher perceived risk of COVID-19 infection were associated with higher acceptance, adjusted odds ratio (aOR): 2.01; 95%CI: 1.01, 4.00 and aOR: 2.21; 95%CI: 1.07, 4.59, respectively; compared to civil servants, being retired was associated with less acceptance (aOR: 0.15; 95%CI: 0.04, 0.63). For a 50% effective vaccine, being a healthcare worker was also associated with greater acceptance, aOR: 1.57; 95%CI: 1.12, 2.20. Conclusion:Acceptance of a COVID-19 vaccine was highly influenced by the baseline effectiveness of the vaccine. Preparing the general population to accept a vaccine with relatively low effectiveness may be difficult.