The direction of actin polymerization for vesicle fission suggested from membranes tubulated by the EFC/F-BAR domain protein FBP17
The direction of actin polymerization for vesicle fission suggested from membranes tubulated by the EFC/F-BAR domain protein FBP17
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DOI：
10.1016/j.febslet.2009.10.019
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发表时间：
2009-11-03
期刊：
影响因子：
3.5
通讯作者：
Suetsugu, Shiro
中科院分区：
文献类型：
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作者：
Suetsugu, Shiro
在网格蛋白依赖的内吞作用过程中，由Arp2/3复合物介导的肌动蛋白聚合对于膜管形成、囊泡形成和分裂是必不可少的。然而，聚合的肌动蛋白丝参与囊泡形成和分裂的机制仍不清楚。我们的分析表明，肌动蛋白聚合朝向FBP17诱导的膜管发生，这些膜管被认为是在内吞囊泡形成过程中产生的。在未来的内吞囊泡和质膜之间的管状膜在囊泡分裂时被认为会形成一个弧形。因此，朝向管状膜的肌动蛋白聚合可能会逐渐转变为朝向囊泡和质膜的聚合。(C) 2009欧洲生物化学学会联合会。由爱思唯尔B.V.出版。保留所有权利。
Actin polymerization mediated by the Arp2/3 complex is essential for membrane tubulation, vesicle formation and fission during clathrin-dependent endocytosis. However, the mechanism by which the polymerizing actin. laments participate in vesicle formation and fission has remained unclear. Our analyses revealed that actin polymerization occurs toward FBP17-induced membrane tubules, which are considered to be generated during endocytic vesicle formation. The tubulated membrane between the future endocytic vesicle and the plasma membrane is proposed to form an arc upon scission of the endocytic vesicle. Therefore, the actin polymerization toward the tubulated membrane may be gradually converted to those toward both the vesicles and the plasma membrane. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.